1076160-56-9

Basic information

• Product Name: (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide
• Synonyms: (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide
• CAS NO: 1076160-56-9
• Molecular Weight: 286.327
• Mol File: 1076160-56-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide(1076160-56-9)
• EPA Substance Registry System: (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide(1076160-56-9)

Safety Data

• Hazardous Substances Data: 1076160-56-9(Hazardous Substances Data)

Usage

Description

(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide is a complex sulfinamide derivative featuring a chiral (R)-configuration at its nitrogen center. It is characterized by a sulfinamide group connected to a substituted phenyl ring with a fluoro and nitro substituent, along with a methylpropane-2-sulfinamide moiety. (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide, due to its unique structural attributes, holds promise for various applications in medicinal and synthetic chemistry.

Uses

Used in Medicinal Chemistry:
(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide is used as a synthetic intermediate for the development of novel pharmaceuticals. Its unique structural features may contribute to distinct pharmacological properties, making it a valuable building block in the creation of functionalized organic molecules with potential therapeutic applications.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide serves as a versatile building block. Its complex molecular structure allows for further functionalization and the synthesis of a wide range of organic compounds with diverse applications, from materials science to pharmaceuticals.
Different applications in different industries may include:
Used in Pharmaceutical Industry:
(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide is used as a key component in the synthesis of new drugs, leveraging its unique structural properties to target specific biological pathways or receptors.
Used in Chemical Research:
In the research and development sector, this compound is used as a model for studying the effects of chirality and functional group substitutions on molecular interactions and reactivity, furthering the understanding of chemical and biological processes.

Upstream product

• 79110-05-7 1-(2-fluoro-5-nitrophenyl)ethanone 
• 445-27-2 2'-Fluoroacetophenone 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1075231-40-1 1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester 
• 1075231-02-5 (R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester 
• 1075231-13-8 (S)-3-(2-fluoro-5-nitro-phenyl)-2,2-dimethyl-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid methyl ester 
• 1075230-63-5 tert-butyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate 
• 1075231-28-5 C₂₅H₃₃FN₂O₆S 
• 1403467-64-0 C₁₃H₁₆FN₃O₄S*ClH 
• 1403467-65-1 C₁₃H₁₈FN₃O₂S 
• 1403466-91-0 C₁₃H₁₇BrFN₃O₂S 
• 1403467-66-2 C₁₉H₂₀F₂N₄O₃S*ClH 
• 1403467-62-8 C₁₉H₂₀F₂N₄O₃S*ClH 
• 1403467-76-4 C₁₃H₁₆FN₃O₄S 
• 1403466-92-1 C₁₃H₁₈FN₃O₂S 
• 1403463-19-3 C₁₉H₂₀ClFN₄O₃S 
• 1403469-34-0 C₁₈H₂₄FN₃O₄S 

Relevant articles and documents

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease

Verubecestat 3 (MK-8931), a diaryl amide-substituted 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative, is a high-affinity β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor currently undergoing Phase 3 clinical evaluation for the treat

IMINOTHIADIAZINE DIOXIDES BEARING AN AMINE-LINKED SUBSTITUENT AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compounds Formula (I): or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, R2, ring A, RA, m, ringB, RB, and n are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

C2-CARBOCYCLIC IMINOTHIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain C2-carbocyclic iminothiazine dioxide compounds, including compounds Formula (I); or a tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, R2, ring A, RA, m, ring B, RB, n, ring C, RC and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.