(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide
• CAS No.: 1076160-56-9
• Molecular Formula: C₁₂H₁₅FN₂O₃S
• Molecular Weight: 286.327
• Mol file: 1076160-56-9.mol

Synonyms:(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

There total 3 articles about (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(2-fluoro-5-nitrophenyl)ethanone (79110-05-7) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide (1076160-56-9)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; for 20h; Reflux;

Reference yield:

(R)-t-butyl sulfinimde + 1-(2-fluoro-5-nitrophenyl)ethanone (79110-05-7) → (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide (1076160-56-9)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; for 20h; Reflux;

Reference yield:

2'-Fluoroacetophenone (445-27-2) → (R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide (1076160-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 0.5 h / -42 °C

2: titanium(IV) tetraethanolate / tetrahydrofuran / 20 h / Reflux

With titanium(IV) tetraethanolate; sulfuric acid; nitric acid; In tetrahydrofuran;

upstream raw materials:

1-(2-fluoro-5-nitrophenyl)ethanone

(R)-2-methylpropane-2-sulfinamide

2'-Fluoroacetophenone

Downstream raw materials:

1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

(S)-3-(2-fluoro-5-nitro-phenyl)-2,2-dimethyl-3-((R)-2-methyl-propane-2-sulfinylamino)-butyric acid methyl ester

tert-butyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate