1076219-11-8Relevant articles and documents
A potent and selective indole N-type calcium channel (Cav2.2) blocker for the treatment of pain
Tyagarajan, Sriram,Chakravarty, Prasun K.,Park, Min,Zhou, Bishan,Herrington, James B.,Ratliff, Kevin,Bugianesi, Randall M.,Williams, Brande,Haedo, Rodolfo J.,Swensen, Andrew M.,Warren, Vivien A.,Smith, McHardy,Garcia, Maria,Kaczorowski, Gregory J.,McManus, Owen B.,Lyons, Kathryn A.,Li, Xiaohua,Madeira, Maria,Karanam, Bindhu,Green, Mitchell,Forrest, Michael J.,Abbadie, Catherine,McGowan, Erin,Mistry, Shruti,Jochnowitz, Nina,Duffy, Joseph L.
, p. 869 - 873 (2011/03/18)
N-type calcium channels (Cav2.2) have been shown to play a critical role in pain. A series of low molecular weight 2-aryl indoles were identified as potent Cav2.2 blockers with good in vitro and in vivo potency.