5379-16-8

Basic information

• Product Name: 3,5-DIMETHYLACETOPHENONE
• Synonyms: 3,5-DIMETHYLACETOPHENONE;1-(3,5-Dimethylphenyl)ethanone;1-(3,5-diMethylphenyl)ethan-1-one;3,5-DiMethylacetoph;3',5'-DiMethylacetophenone, 98%+
• CAS NO: 5379-16-8
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• EINECS: 1533716-785-6
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines
• Mol File: 5379-16-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 20°C
• Boiling Point: 98-100°C 8mm
• Flash Point: 98-100°C/8mm
• Appearance: /
• Density: 0,988 g/cm3
• Refractive Index: 1.5290
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2240987
• CAS DataBase Reference: 3,5-DIMETHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIMETHYLACETOPHENONE(5379-16-8)
• EPA Substance Registry System: 3,5-DIMETHYLACETOPHENONE(5379-16-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 5379-16-8(Hazardous Substances Data)

Usage

General Description

3,5-DIMETHYLACETOPHENONE is a chemical compound with the molecular formula C10H12O. It is a ketone with a distinct aromatic odor and is commonly used as a flavor and fragrance ingredient in the food and cosmetic industry. Its main applications include the production of perfumes, colognes, and other scented products. Additionally, 3,5-DIMETHYLACETOPHENONE is also used in the synthesis of pharmaceuticals and other organic compounds. It is a clear, colorless liquid at room temperature and is considered to be relatively stable under normal conditions.

InChI:InChI=1S/C10H12O/c1-7-4-8(2)6-10(5-7)9(3)11/h4-6H,1-3H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 22445-42-7 3,5-dimethylbenzonitrile 
• 2142-73-6 1-(2,5-dimethylphenyl)-1-ethanone 
• 5379-18-0 rac-1-(3,5-dimethylphenyl)ethan-1-ol 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 108-24-7 acetic anhydride 
• 34696-73-6 3,5-dimethyphenylmagnesium bromide 
• 14646-21-0 1,3-dimethyl-5-(prop-1-en-2-yl)benzene 
• 431-03-8 dimethylglyoxal 
• 1249159-79-2 C₈H₁₂N₂O₂S 
• 75-05-8 acetonitrile 
• 556-96-7 5-bromo-1,3-xylene 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 1123-09-7 3,5-dimethyl-2-cyclohexen-1-one 

Downstream Products

• 276856-74-7 methyl (Z)-3-(3,5)-xylyl-2-butenoate 
• 136942-14-8 1-(3,5-dimethylphenyl)-3-phenylpropane-1,3-dione 
• 1285694-92-9 2,4-bis(3,5-dimethylphenyl)pyridine 
• 1076219-11-8 ethyl 2-[2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropanoate 
• 1269206-80-5 2-(1-(3,5-dimethylphenyl)ethyl)benzo[d]oxazole 
• 1269207-48-8 C₁₇H₂₀N₂O₂S 
• 1404491-67-3 2-(3,5-dimethylphenyl)-5-isobutylquinoline 
• 1455472-59-9 (1S)-2-bromo-1-(3,5-dimethylphenyl)ethan-1-ol 
• 1455472-60-2 (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)ethanol 
• 1455472-61-3 (S)-2-((3S)-3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)-1-(3,5-dimethylphenyl)-N-methylethanamine 
• 1101187-10-3 1,3-dimethyl-5-(2-pyridyl)benzene 
• 934-74-7 1-ethyl-3,5-dimethylbenzene 

Relevant articles and documents

Decatungstate-mediated solar photooxidative cleavage of CC bonds using air as an oxidant in water

With the increasing attention for green chemistry and sustainable development, there has been much interest in searching for greener methods and sources in organic synthesis. However, toxic additives or solvents are inevitably involved in most organic transformations. Herein, we first report the combination of direct utilization of solar energy, air as the oxidant and water as the solvent for the selective cleavage of CC double bonds in aryl olefins. Various α-methyl styrenes, diaryl alkenes as well as terminal styrenes are well tolerated in this green and sustainable strategy and furnished the desired carbonyl products in satisfactory yields. Like heterogeneous catalysis, this homogeneous catalytic system could also be reused and it retains good activity even after repeating three times. Mechanism investigations indicated that both O2- and 1O2 were involved in the reaction. Based on these results, two possible mechanisms, including the electron transfer pathway and the energy transfer pathway, were proposed.

Metal-Free Photoinduced Transformation of Aryl Halides and Diketones into Aryl Ketones

The acylation of aryl halides to prepare aryl ketones without metal catalyst represents an important yet challenging topic towards more sustainable ketone synthesis. Herein, we describe a simple and efficient metal-free protocol for the acylation of aryl halides with diketone under the irradiation of light utilizing N-methylpiperidine as base under an air atmosphere. This reaction can tolerate a wide range of functional groups and the corresponding ketones can be obtained in modest to good yields.

Pd(II)-Catalyzed Denitrogenative and Desulfinative Addition of Arylsulfonyl Hydrazides with Nitriles

A Pd(II)-catalyzed denitrogenative and desulfinative addition of arylsulfonyl hydrazides with nitriles has been successfully achieved under mild conditions. This transformation is a new method for the addition reaction to nitriles with arylsulfonyl hydrazides as arylating agent, thus providing an alternative synthesis of aryl ketones. The reported addition reaction is tolerant to many common functional groups, and works well in the presence of electron-donating and electron-withdrawing substituents. Notably, the reported denitrogenative and desulfinative addition was also appropriate for alkyl nitriles, making this newly developed transformation attractive.