107623-97-2 Usage
Uses
Used in Chemical Synthesis:
2'-Chloro-2-hydroxy-4-methylbenzophenone is used as a key intermediate in the synthesis of various organic compounds, particularly in the production of (4-hydroxy-6-methyl-1,3-phenylene)bis[(2-chlorophenyl)methanone. 2'-CHLORO-2-HYDROXY-4-METHYLBENZOPHEN& serves as a building block for creating more complex molecules with specific properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-chloro-2-hydroxy-4-methylbenzophenone may be utilized as a starting material for the development of new drugs or drug candidates. Its unique chemical structure can be further modified to create molecules with potential therapeutic effects.
Used in Dye and Pigment Industry:
The compound may also find applications in the dye and pigment industry, where it can be used to produce colorants with specific properties, such as lightfastness, stability, and color intensity.
Used in Material Science:
2'-Chloro-2-hydroxy-4-methylbenzophenone can be employed in the development of advanced materials, such as polymers, with tailored properties for various applications, including electronics, coatings, and adhesives.
Preparation
Preparation by Fries rearrangement of m-cresyl o-chloro-benzoate, ? with polyphosphoric acid at 130° for 40 min (87%); ? with aluminium chloride between 120° and 160° for 2 h.
Check Digit Verification of cas no
The CAS Registry Mumber 107623-97-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,6,2 and 3 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 107623-97:
(8*1)+(7*0)+(6*7)+(5*6)+(4*2)+(3*3)+(2*9)+(1*7)=122
122 % 10 = 2
So 107623-97-2 is a valid CAS Registry Number.
107623-97-2Relevant academic research and scientific papers
Direct acylation of phenol and naphthol derivatives in a mixture of graphite and methanesulfonic acid
Sharghi, Hashem,Hosseini-Sarvari, Mona,Eskandari, Razieh
, p. 2047 - 2052 (2007/10/03)
Graphite in methanesulfonic acid is used to prepare o-hydroxyketones by direct acylation of phenol and naphthol derivatives with carboxylic acids. Georg Thieme Verlag Stuttgart.
Alumina in Methanesulfonic Acid (AMA) as a New Efficient Reagent for Direct Acylation of Phenol Derivatives and Fries Rearrangement. A Convenient Synthesis of o-Hydroxyarylketones
Sharghi, Hashem,Kaboudin, Babak
, p. 2678 - 2695 (2007/10/03)
Alumina in methanesulfonic acid (AMA) is used to prepare o-hydroxyaryl ketones by acylation of phenol and naphthol derivatives with carboxylic acids and the Fries rearrangement of phenolic esters. Mechanistic studies show that the acylation reaction in AMA occurred through an esterification followed by a Fries rearrangement of the phenolic ester by an intermolecular mechanism.
The Mechanism of Fries Rearrangement and Acylation Reaction in Polyphosphoric Acid
Sharghi, Hashem,Eshghi, Hossien
, p. 135 - 139 (2007/10/02)
Acylation reaction of m-cresol with 2-chlorobenzoic acid in PPA occurred through a prior esterification, followed by a Fries rearrangement of ester (3) to give benzophenones 4-7.Ester 3 undergoes the Fries rearrangement in PPA, giving benzophenones 4-7 in
