107623-97-2

Basic information

• Product Name: 2'-CHLORO-2-HYDROXY-4-METHYLBENZOPHEN&
• Synonyms: 2'-CHLORO-2-HYDROXY-4-METHYLBENZOPHEN&
• CAS NO: 107623-97-2
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.692
• Product Categories: C13 to C14;Carbonyl Compounds;Ketones
• Mol File: 107623-97-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 107-109 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 2'-CHLORO-2-HYDROXY-4-METHYLBENZOPHEN&(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-CHLORO-2-HYDROXY-4-METHYLBENZOPHEN&(107623-97-2)
• EPA Substance Registry System: 2'-CHLORO-2-HYDROXY-4-METHYLBENZOPHEN&(107623-97-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 107623-97-2(Hazardous Substances Data)

Usage

Uses

2′-Chloro-2-hydroxy-4-methylbenzophenone may be used in the synthesis of (4-hydroxy-6-methyl-1,3-phenylene)bis[(2-chlorophenyl)methanone.

Preparation

Preparation by Fries rearrangement of m-cresyl o-chloro-benzoate, ? with polyphosphoric acid at 130° for 40 min (87%); ? with aluminium chloride between 120° and 160° for 2 h.

Upstream product

• 108-39-4 3-methyl-phenol 
• 118-91-2 ortho-chlorobenzoic acid 
• 32357-12-3 3-methylphenyl 2-chlorobenzoate 
• 92103-15-6 2'-chloro-4-hydroxy-2-methylbenzophenone 

Relevant articles and documents

Direct acylation of phenol and naphthol derivatives in a mixture of graphite and methanesulfonic acid

Graphite in methanesulfonic acid is used to prepare o-hydroxyketones by direct acylation of phenol and naphthol derivatives with carboxylic acids. Georg Thieme Verlag Stuttgart.

The Mechanism of Fries Rearrangement and Acylation Reaction in Polyphosphoric Acid

Acylation reaction of m-cresol with 2-chlorobenzoic acid in PPA occurred through a prior esterification, followed by a Fries rearrangement of ester (3) to give benzophenones 4-7.Ester 3 undergoes the Fries rearrangement in PPA, giving benzophenones 4-7 in