32357-12-3

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 108-39-4 3-methyl-phenol 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 107623-97-2 2'-chloro-2-hydroxy-4-methylbenzophenone 
• 114330-15-3 1-(2-chloro-benzyl)-4-(3,5-dinitro-benzoyloxy)-2-methyl-benzene 
• 110029-35-1 4-(2-chloro-benzyl)-3-methyl-phenol 
• 64358-10-7 2-chloro-2',4'-dimethylbenzophenone 
• 92103-15-6 2'-chloro-4-hydroxy-2-methylbenzophenone 

Relevant academic research and scientific papers

Alumina in Methanesulfonic Acid (AMA) as a New Efficient Reagent for Direct Acylation of Phenol Derivatives and Fries Rearrangement. A Convenient Synthesis of o-Hydroxyarylketones

Alumina in methanesulfonic acid (AMA) is used to prepare o-hydroxyaryl ketones by acylation of phenol and naphthol derivatives with carboxylic acids and the Fries rearrangement of phenolic esters. Mechanistic studies show that the acylation reaction in AMA occurred through an esterification followed by a Fries rearrangement of the phenolic ester by an intermolecular mechanism.

The Mechanism of Fries Rearrangement and Acylation Reaction in Polyphosphoric Acid

Acylation reaction of m-cresol with 2-chlorobenzoic acid in PPA occurred through a prior esterification, followed by a Fries rearrangement of ester (3) to give benzophenones 4-7.Ester 3 undergoes the Fries rearrangement in PPA, giving benzophenones 4-7 in