107625-40-1Relevant articles and documents
Rh/Cu-Catalyzed Ketone β-Functionalization by Merging Ketone Dehydrogenation and Carboxyl-Directed C-H Alkylation
Li, Hongyi,Jiang, Quandi,Jie, Xiaoming,Shang, Yaping,Zhang, Yuanfei,Goossen, Lukas J.,Su, Weiping
, p. 4777 - 4782 (2018)
An efficient Rh/Cu-catalyzed method has been developed for the direct β-arylation or alkenylation of ketones using (hetero)aryl or alkenyl carboxylic acids as coupling partners. This direct ketone β-functionalization reaction proceeded via the merging of Cu-catalyzed ketone dehydrogenative desaturation and Rh-catalyzed carboxyl-directed C-H alkylation, exhibiting a broad substrate scope for both coupling partners. TEMPO proved to be essential for both dehydrogenation process and generation of the active Rh catalyst for C-H activation.