107642-74-0

Upstream product

• 49820-06-6 4,6-dimethyl-1H-indole-2,3-dione 
• 98-59-9 p-toluenesulfonyl chloride 
• 941-55-9 4-toluenesulfonyl azide 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 1570134-98-3 N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-2,4-dimethyl-6-(4-methylphenylsulfonamido)benzamide 
• 90321-33-8 2-amino-4,6-dimethyl-benzoic acid 

Downstream Products

• 107642-75-1 4-methoxy-3,4',5,6'-tetramethyl-2'-(4-toluenesulphonamino)diphenyl ketone 
• 114097-28-8 N-(3,5-dimethylphenyl)-4-methyl-benzenesulfonamide 
• 107642-76-2 2'-amino-4-methoxy-3,4',5,6'-tetramethyldiphenyl ketone 

Relevant academic research and scientific papers

Method for Preparing Derivatives of Anthranilic acid and Anti-inflammatory Use Thereof

The present invention relates to a production method of anthranilic acid derivatives which reacts benzoic acid derivatives and phenylsulfonyl azide derivatives under the presence of a [IrCp*Cl_2]_2 catalyst; and relates to an anti-inflammatory use of the

Direct C-H amidation of benzoic acids to introduce meta- and para-amino groups by tandem decarboxylation

The Ir-catalyzed mild C-H amidation of benzoic acids with sulfonyl azides was developed to give reactions with high efficiency and functional-group compatibility. Subsequent protodecarboxylation of ortho-amidated benzoic acid products afforded meta- or para-substituted (N-sulfonyl)aniline derivatives, the latter being inaccessible by other C-H functionalization approaches. The decarboxylation step was compatible with the amidation conditions, enabling a convenient one-pot, two-step process. Without a trace: Carboxylic acids are used as traceless directing groups in the Ir-catalyzed direct C-H amidation of arenes with sulfonyl azides under mild conditions. The tandem protodecarboxylation of the ortho-amidated benzoic acid products afforded meta- or para-substituted (N-sulfonyl)anilines, which are difficult to obtain by other C-H functionalization approaches.

Cu(II)-mediated C-H amidation and amination of arenes: Exceptional compatibility with heterocycles

A Cu(OAc)2-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group. A wide range of sulfonamides, amides, and anilines function as amine donors in this reaction. Heterocycles present in both reactants are tolerated, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzoates.

SIGMATROPIC REARRANGEMENT OF ARYLHYDRAZONES FOLLOWED BY 1,2-SHIFT OF AN ARYL GROUP. VII

Arylhydrazones of ethyl 4-methoxy-3,5-dimethylphenylglyoxylate and 4-methoxy-3,5-dimethylacetophenone rearrange in hot polyphosphoric acid to give biphenyl derivatives arising from a sigmatropic rearrangement followed by an aryl group 1,2-shift.Stru