107646-64-0

Upstream product

• 1746-13-0 allyl phenyl ether 
• 122-60-1 Phenyl glycidyl ether 
• 106-89-8 epichlorohydrin 
• 108-95-2 phenol 

Relevant academic research and scientific papers

Regioselective conversion of unsymmetrical terminal epoxides into vicinal chlorohydrins using dimethoxyboron chloride

A highly regioselective synthesis of chlorohydrins by chlorinative cleavage of unsymmetrical epoxides utilizing dimethoxyboron chloride is described. Except for styrene oxide, all the terminal epoxides were regioselectively cleaved following a predominantly SN2-type reaction pathway favouring the formation of primary chlorides. In the case of styrene oxide, a benzylic epoxide, (MeO)2BCl transfers the chlorine at the benzylic position, by following an apparent SN1-type mechanism. CSIRO 2006.

Synthesis, Characterization, and Evaluation of Surface and Thermal Properties and Cytotoxicity of 2-Hydroxy-3-Phenoxypropyl Imidazolium Bola-Type Gemini Amphiphiles

A library of imidazolium-based gemini cationic bola amphiphiles was synthesized using a regioselective ring-opening reaction of glycidyl phenyl ether with imidazole under solvent-free conditions. The corresponding hexafluorophosphate (PF6?) and tetrafluoroborate (BF4?) counterion-containing amphiphiles were also synthesized and characterized using nuclear magnetic resonance (NMR) and mass spectroscopy. The micellar and interfacial parameters like the critical micelle concentration (CMC), surface pressure at the CMC (Пcmc), surface tension at CMC (γcmc), counterion binding (β), maximum surface excess concentration (Γmax), minimum area per molecule (Amin), standard free energy of micellization (ΔG0mic) and adsorption (ΔG0ads), and Kraft temperature were evaluated using surface tension and conductometry methods in aqueous solution as well as in buffer solution. Dynamic light scattering (DLS) was used to determine the size of the micelles formed in the aqueous solution. Cytotoxicity tests were carried out on the C6 glioma cancerous brain cell line using the MTT assay (3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazolium bromide) to evaluate the IC50 value of all the synthesized amphiphiles. Thermal stability of these amphiphiles was also evaluated using a thermal gravimetric analyzer (TGA). Economic way of synthesis, moderate thermal stability, a low value of CMC, and cytotoxicity of these amphiphiles will inspire new research in the field of nanobiotechnology and pharmaceutical industries.

Convenient synthesis of chlorohydrins from epoxides using zinc oxide: Application to 5,6-epoxysitosterol

Efficient synthesis of protected and unprotected chlorohydrins has been achieved by ring opening of epoxides with acetyl/benzoyl chloride and TMSCl using a catalytic amount of ZnO as a reusable catalyst. The applicability of ZnO is further extended by performing the cleavage of the natural product 5,6-epoxysitosterol with acetyl chloride.

An Easy and Efficient Epoxide Opening to give Halohydrins using Tin(II) Halides

Epoxides are readily converted into halohydrins by tin(II) halides in a variety of solvents.