107668-79-1 Usage
Description
Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted
from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called
dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming
Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A
can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou
(Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).
Physical properties
Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform,
and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or
dilute sulfuric acid . Melting point: 160–165?°C
History
In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were
carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan
Honghe Pingbian pharmaceutical company, where it obtained the trade name
“Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of
the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown
a great market growth and competitive power, owing to its exact curative effect and
rapid clinical promotion in chronic disease and rheumatic immune disease.
Pharmacology
1. Anti-inflammatory and analgesic effect. Bulleyaconitine A plays a significant
anti-inflammatory effect by inhibiting the release of prostaglandins. The analgesic effect may be related to the rivalry of 5-HT and the inhibition of inflammatory
chemokines in the brain, because inhibition of PGE2 release may lead to disinhibition of β-endorphin . Further studies showed that bulleyaconitine A achieved
the analgesic effect by effectively reducing sodium ion current, the electrophysiological basis on which pain conduction is dependent . Zhanguo Niu et?al.
found that bulleyaconitine A could be used to treat mild and moderate burn pain,
with less adverse reactions and no addiction . Thus, bulleyaconitine A may be
suitable for long-term use as a choice of analgesic therapy for burn pain. Recently,
through clinical observation on the effect of bulleyaconitine A treatment in acute
gouty arthritis, some scholars discovered that bulleyaconitine A brought about
good effect and could effectively improve the clinical symptoms of patients by
taking 0.4?mg bulleyaconitine A orally three times in daily .2. Immune regulation. Bulleyaconitine A has obvious inhibitory effects to immune
cells involved in joint inflammation, which may have a close relationship to its
clinical anti-inflammatory effect. Ye Lu et?al. studied the influence of bulleyaconitine A on partial immune functions of BALB/c mice and found that 0.32?mg/kg
bulleyaconitine A inhibits some immune functions of BALB/c mice . Moreover,
it was reported that bulleyaconitine A significantly inhibited the phagocytic function and the ability to secrete nitric oxide (NO) of macrophages .3. Other pharmacological effects. An injection of 0.1 mg/kg bulleyaconitin A in
fasting rat can inhibit the formation of corneal neovascularization induced by
alkali burn . Bulleyaconitine A also has local anesthesia and antipyretic effect.
Besides, bulleyaconitine A can be used for the treatment of lumbar muscle strain,
scapulohumeral periarthritis, and sprain of limbs.
Clinical Use
1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in
clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good
curative effects.2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its
effects by regulating the sodium ion channel. So there is little psychological
dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal
adverse reactions and drug dependence or other potential dangers caused by
NSAID and opioid analgesics.
Check Digit Verification of cas no
The CAS Registry Mumber 107668-79-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,6,6 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 107668-79:
(8*1)+(7*0)+(6*7)+(5*6)+(4*6)+(3*8)+(2*7)+(1*9)=151
151 % 10 = 1
So 107668-79-1 is a valid CAS Registry Number.
InChI:InChI=1/C35H49NO9/c1-8-36-17-32(18-40-3)14-13-23(42-5)35-22-15-33(39)24(43-6)16-34(45-19(2)37,27(31(35)36)29(44-7)30(32)35)25(22)26(33)28(38)20-9-11-21(41-4)12-10-20/h9-12,22-27,29-31,39H,8,13-18H2,1-7H3
