107680-51-3Relevant academic research and scientific papers
A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin
Rizzi, Eleonora,Dallavalle, Sabrina,Merlini, Lucio,Beretta, Giovanni Luca,Pratesi, Graziella,Zunino, Franco
, p. 4313 - 4316 (2007/10/03)
A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.
Synthesis of Z-Marginalin and Identification of the Natural Product as the E Isomer
Barbier, Michel
, p. 545 - 546 (2007/10/02)
The base-catalyzed reaction of p-hydroxybenzaldehyde (1) with (2,5-dihydroxyphenyl)acetic acid γ-lactone (2) directly gives Z-marginalin (3) with 60percent yield.Comparisons of the physical properties with reported data of the substance isolated from the beetle Dytiscus marginalis and of a synthetic product previously obtained through a different method establish the E structure (4) for the natural marginalin.
