1077-24-3

Basic information

• Product Name: 3-P-TOLYLAMINO-PROPIONITRILE
• Synonyms: 3-(P-TOLUIDINO)PROPIONITRILE
• CAS NO: 1077-24-3
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 160.22
• Mol File: 1077-24-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 335.3 °C at 760 mmHg
• Flash Point: 156.6 °C
• Appearance: /
• Density: 1.057 g/cm³
• Vapor Pressure: 0.000121mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 3-P-TOLYLAMINO-PROPIONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-P-TOLYLAMINO-PROPIONITRILE(1077-24-3)
• EPA Substance Registry System: 3-P-TOLYLAMINO-PROPIONITRILE(1077-24-3)

Safety Data

• Hazardous Substances Data: 1077-24-3(Hazardous Substances Data)

Usage

General Description

3-P-Tolylamino-propionitrile is a chemical compound with the molecular formula C10H11N. It is a yellow solid that is commonly used in the pharmaceutical industry as a precursor in the synthesis of various drugs. 3-P-TOLYLAMINO-PROPIONITRILE is also known for its role in the production of dyes and other organic compounds. Additionally, 3-P-Tolylamino-propionitrile is used in research and development as a building block for the synthesis of new materials and compounds. Due to its versatile nature and application in various industries, this chemical is of great interest to scientists and manufacturers alike.

InChI:InChI=1/C10H12N2/c1-9-3-5-10(6-4-9)12-8-2-7-11/h3-6,12H,2,8H2,1H3

Upstream product

• 5198-46-9 3-(4-methylphenyl)-2-oxazolidinone 
• 334705-70-3 Pt(2,6-(Ph₂PCH₂)2C₆H₃)(CH(CN)CH₂NH(C₆H₄Me-p)) 
• 122146-98-9 [NH₃(C₆H₄Me-p)]BPh₄ 
• 106-49-0 p-toluidine 
• 96248-18-9 N,N-Bis-<2-cyan-aethyl>-norleucin 
• 107-13-1 acrylonitrile 
• 5351-04-2 3-diethylaminopropionitrile 

Downstream Products

• 27418-59-3 3-(p-methylphenylamino)propanoic acid 
• 138652-97-8 3-[(2-Oxo-2-phenyl-ethyl)-p-tolyl-amino]-propionitrile 
• 117461-59-3 N-cyanoethyl-2,5-dimethyl-3-phenylindol 
• 117461-60-6 N-propylamino-2,5-dimethyl-3-phenylindol 
• 138653-48-2 9-Methyl-1,11-diphenyl-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indole 
• 138653-41-5 9,11-Dimethyl-1-phenyl-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indole 

Relevant articles and documents

Synthesis and pharmacological evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile derivatives as orally active AMPA receptor antagonists

In our search for novel orally active α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, we found that conversion of an allyl group in the lead compound 2-[allyl(4-methyl-phenyl)amino]-4H-pyrido[3,2-e][1,3]thiazin-4-one (4)

A green and convenient approach for the one-pot solvent-free synthesis of coumarins and β-amino carbonyl compounds using Lewis acid grafted sulfonated carbon@titania composite

Abstract: This paper reports an efficient protocol for the synthesis of coumarins via Pechmann reaction, and β-amino carbonyl compounds via aza-Michael reaction using catalytic amount of solid Lewis acid catalyst, C@TiO2–SO3–SbCl2. Six different catalysts were prepared by covalent immobilization of homogeneous Lewis acids onto sulfonated carbon@titania composite derived from amorphous carbon and nano-titania. Among various catalysts tested, C@TiO2–SO3–SbCl2 showed superior catalytic activity. The catalyst could be recycled without significant loss of its catalytic activity and demonstrated versatile catalysis for a wide range of substrates. Graphical abstract: [Figure not available: see fulltext.]

Copper-Catalyzed Aza-Michael Addition of Aromatic Amines or Aromatic Aza-Heterocycles to α,β-Unsaturated Olefins

A highly efficient and mild Cu-catalyzed conjugate addition reaction of aromatic amines and aromatic aza-heterocycles to α,β-unsaturated olefins is described. The transformation is promoted by 3-7 mol % of a Cu complex generated in situ from a mixture of inexpensive CuCl, a readily available phosphine or imidazolium salt, and KOt-Bu at ambient temperature. A wide range of β-amino sulfone, β-amino nitrile, and β-amino carbonyl compounds is efficiently and selectively synthesized in high yields (62-99%).