5198-46-9

Basic information

• Product Name: 3-(4-Methylphenyl)-1,3-oxazolidin-2-one
• Synonyms: 3-(4-Methylphenyl)-1,3-oxazolidin-2-one
• CAS NO: 5198-46-9
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 5198-46-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 91 °C
• Boiling Point: 287.9°C at 760 mmHg
• Flash Point: 127.9°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.568
• PKA: 0.75±0.20(Predicted)
• CAS DataBase Reference: 3-(4-Methylphenyl)-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methylphenyl)-1,3-oxazolidin-2-one(5198-46-9)
• EPA Substance Registry System: 3-(4-Methylphenyl)-1,3-oxazolidin-2-one(5198-46-9)

Safety Data

• Hazardous Substances Data: 5198-46-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NO2/c1-8-2-4-9(5-3-8)11-6-7-13-10(11)12/h2-5H,6-7H2,1H3

Upstream product

• 106-49-0 p-toluidine 
• 124-38-9 carbon dioxide 
• 107-06-2 1,2-dichloro-ethane 
• 106-93-4 ethylene dibromide 
• 627-11-2 2-Chloroethyl chloroformate 
• 5602-93-7 ethyl (2-hydroxyethyl)carbamate 
• 624-31-7 4-tolyl iodide 
• 75-21-8 oxirane 
• 14618-59-8 N-(tert-butoxycarbonyl)-4-methylaniline 
• 497-25-6 dimethylenecyclourethane 
• 5720-05-8 4-methylphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 74552-28-6 N-(p-Tolyl)carbamidsaeure-β-chlorethylester 
• 96-49-1 [1,3]-dioxolan-2-one 

Downstream Products

• 2933-74-6 2-[(4-methylphenyl)amino]-ethanol 
• 71472-58-7 3,4-dihydro-7-methyl-2H-1,4-benzoxazine 
• 1313524-80-9 C₁₆H₁₃Cl₂NO₂ 
• 1313524-81-0 C₁₆H₁₃F₂NO₂ 
• 1313524-82-1 C₁₆H₁₃ClFNO₂ 
• 1077-24-3 3-(p-tolylamino)propionitrile 
• 28690-22-4 3-(p-tolyl)thiazolidin-2-one 

Relevant articles and documents

Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides

N,N′-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between

METHODS FOR PREPARING BENZOXAZINES

A method is provided for preparing a compound / the method comprising carrying out the following reaction: Formula (i); Formula (ii) where: R10 is hydrogen or a hydroxy protecting group; PG is an amine protecting group; and q is 1 where PG is a

Synthesis of N-aryl-2-oxazolidinones from cyclic carbonates and aromatic amines catalyzed by bio-catalyst

A convenient and effective method of synthesizing 3-aryl-2-oxazolidinones from cyclic carbonates and aryl amines catalyzed by bio-catalyst adenine in the presence of Et3N under solvent-free conditions is described. The protocol is suitable for the wide scope of substrates, e.g. cyclic carbonates with or without substitutes, and aryl amines with either electron-withdrawing or electron-donating group. The products were obtained in good to excellent yields under the optimal conditions, even in steric hindered cases. The effect of reaction time, temperature, loading of catalyst, and amount of starting materials in the reaction were investigated, and the reaction mechanism is discussed.