1077-96-9

Basic information

• Product Name: 5-Fluoro-3-indazolecarboxylic acid
• Synonyms: 5-FLUORO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-Fuloro-1H-indazole-3-carboxylic acid;5-FLUORO-INDAZOLE-3-CARBOXYLIC ACID;5-FLUORO-3-INDAZOLECARBOXYLIC ACID;5-FLUORO-INDOZOLE-3-CARBOXYLIC ACID;1H-Indazole-3-carboxylic acid, 5-fluoro-;5-fluoro-1H-indazol-3-carboxylic acid;5-Fuoro-1H-indazole-3-carboxylic acid
• CAS NO: 1077-96-9
• Molecular Formula: C₈H₅FN₂O₂
• Molecular Weight: 180.14
• Product Categories: pharmacetical;Indazole
• Mol File: 1077-96-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 299 °C
• Boiling Point: 445.851°C at 760 mmHg
• Flash Point: 223.443°C
• Appearance: /
• Density: 1.611 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: 2-8°C
• PKA: 2.89±0.30(Predicted)
• CAS DataBase Reference: 5-Fluoro-3-indazolecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-3-indazolecarboxylic acid(1077-96-9)
• EPA Substance Registry System: 5-Fluoro-3-indazolecarboxylic acid(1077-96-9)

Safety Data

• Hazardous Substances Data: 1077-96-9(Hazardous Substances Data)

Usage

Chemical Properties

yellow powder

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 1, p. 239, 1964 DOI: 10.1002/jhet.5570010505

InChI:InChI=1/C8H5FN2O2/c9-4-1-2-6-5(3-4)7(8(12)13)11-10-6/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 443-69-6 5-fluoro-1H-indole-2,3-dione 

Downstream Products

• 78155-73-4 methyl 5-fluoro-1H-indazole-3-carboxylate 
• 485841-48-3 5-fluoro-1H-indazole-3-carbaldehyde 
• 518990-02-8 (5-fluoro-1H-indazol-3-yl)methanol 
• 1309060-66-9 N-((5-(2-(2-(1H-imidazol-1-yl)ethyl)-5-fluoro-2H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methyl)-2,3-dimethoxybenzamide 
• 1448314-60-0 5-fluoro-1-(3-methylbenzoyl)-1H-indazole-3-carboxylic acid ethyl ester 
• 1016-36-0 5-fluoro-1⁽²⁾H-indazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

INDAZOLE DERIVATIVES AND THEIR USE FOR BLOCKADING VOLTAGE DEPENDENT SODIUM CHANNELS

The invention provides an indazole derivative of formula (1), or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1, R2, R3 and R4 are as defined herein. The indazole derivatives are capable of bl

Tricyclic heterocycles

The present invention relates to the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing suc