78155-73-4

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE is used as a building block for the synthesis of various pharmaceutical drugs due to its ability to contribute to the development of bioactive molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE is utilized as a precursor in the creation of compounds with antifungal and antibacterial properties, which are essential for crop protection and disease management.
Used in Drug Discovery and Development:
METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE is employed as a valuable precursor in drug discovery and development because of its wide range of biological activities, making it suitable for the design and synthesis of new drugs targeting various diseases.
Used in the Treatment of Cancer:
METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE is used as a potential therapeutic agent in cancer treatment, given its ability to modulate biological pathways and target specific enzymes that play a role in cancer progression.
Used in the Treatment of Neurological Disorders:
METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE is also used in the development of treatments for neurological disorders, capitalizing on its capacity to influence relevant biological pathways and potentially alleviate symptoms or slow disease progression.

Upstream product

• 67-56-1 methanol 
• 1077-96-9 5-fluoro-1H-indazole-3-carboxylic acid 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 348-26-5 5-fluoro-1H-indazole 
• 201230-82-2 carbon monoxide 
• 858629-06-8 5-fluoro-3-iodo-1H-indazole 
• 1314926-95-8 5-fluoroisatin 

Downstream Products

• 518990-02-8 (5-fluoro-1H-indazol-3-yl)methanol 
• 485841-48-3 5-fluoro-1H-indazole-3-carbaldehyde 

Relevant academic research and scientific papers

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

Synthesis of 3-indazolecarboxylic esters and amides via Pd-catalyzed carbonylation of 3-iodoindazoles

A straightforward and effective procedure for the preparation of 1H-indazole-3-carboxylic acid esters and amides was developed. A series of functionalized 3-iodoindazoles were subjected to Pd-catalyzed carbonylations in the presence of methanol or amines,

Quantum mechanical study and vibrational spectra of indazolium-3- carboxylate and its decarboxylation product, the N-heterocyclic carbene indazol-3-ylidene

Indazolium-3-carboxylate is a molecule that can be found as the nucleus of several pseudo-cross-conjugated mesomeric betaines, such as the alkaloid nigellicine. From a chemical point of view, one of the more interesting properties of this class of molecules is the possibility of forming an N-heterocyclic carbene by thermal decarboxylation. In this paper we have studied the carbene generation by decarboxylation of 1,2-dimethyl indazolium-3- carboxylate, using vibrational (infrared and Raman) spectroscopy and quantum chemistry calculations. Normal mode analysis allowed us to analyse the changes in the stretching force constants upon decarboxylation and to establish spectroscopic-structure relationships. We also investigate the effect of 5-halogen (fluoro, chloro) substitution on the carbene generation. Decarboxylation energy profiles of the three derivatives were calculated. Crossing of the energy paths when going from the transition state to the final product were obtained. The theoretical tendency found for the activation energies agrees with that observed for the decarboxylation temperatures and for the calculated NICS values of the benzene moieties. the Owner Societies.

CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II

The invention discloses compounds of formula (I) wherein: R is a carboxylic acid or a derivative thereof; R1 and R2 are independently H or alkyl, or together R1 and R2 form an alkylene group; L1 is a

N-heterocyclic carbenes of 5-haloindazoles generated by decarboxylation of 5-haloindazolium-3-carboxylates

Syntheses and properties of 5-fluoro-, chloro- bromo-, and iodo-substituted 11,2-dimethylindazohum-3-carboxylates as new representatives of pseudo-cross-conjugated heterocyclic mesomeric betaines are described, and results of an X-ray single crystal analy