107716-34-7

Basic information

• Product Name: diethyl N-<4-ethyl>-N-methylamino>benzoyl>-L-glutamate
• Synonyms: diethyl N-<4-ethyl>-N-methylamino>benzoyl>-L-glutamate
• CAS NO: 107716-34-7
• Molecular Weight: 502.571
• Mol File: 107716-34-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl N-<4-ethyl>-N-methylamino>benzoyl>-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl N-<4-ethyl>-N-methylamino>benzoyl>-L-glutamate(107716-34-7)
• EPA Substance Registry System: diethyl N-<4-ethyl>-N-methylamino>benzoyl>-L-glutamate(107716-34-7)

Safety Data

• Hazardous Substances Data: 107716-34-7(Hazardous Substances Data)

Upstream product

• 115827-03-7 diethyl N--L-glutamate 
• 70280-70-5 diethyl N--L-glutamate 
• 107716-30-3 diethyl N-<4-benzoyl>-L-glutamate 
• 2378-95-2 diethyl N-<4-(methylamino)benzoyl>-L-glutamate 
• 13726-52-8 diethyl N-(p-aminobenzoyl)-L-glutamate 
• 4214-86-2 2,5-diamino-4-oxo-6-methyl pyrimidine 
• 107716-32-5 diethyl N-<4-benzoyl>-L-glutamate 

Downstream Products

• 107716-42-7 N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamic acid 5'-monophosphate 
• 107716-38-1 diethyl N-<4-amino>ethyl>-N-methylamino>benzoyl>-L-glutamate 

Relevant articles and documents

A pyrimidine-based 'flexible' bisubstrate analogue inhibitor of human thymidylate synthase

The synthesis and characterization of two 'flexible' bisubstrate analogues of the intermediate in the thymidylate synthase reaction are reported. Steric constraints are minimized and diasteromeric mixtures avoided by using a pyrimidine-based analogue as the folate portion of the inhibitor while retaining all known important binding sites. A preliminary assessment of certain conformational parameters by NMR is presented. The compounds are shown to be potent competitive inhibitors with respect to dUMP or 5,10-CH2-H4PteGlu but gave mixed kinetics with respect to 5,10-CH2-H4PteGlu5 for human thymidylate synthase.