107734-23-6

Basic information

• Product Name: 4-nitro-2-vinylaniline
• Synonyms: 4-nitro-2-vinylaniline
• CAS NO: 107734-23-6
• Molecular Weight: 164.164
• Mol File: 107734-23-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-nitro-2-vinylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitro-2-vinylaniline(107734-23-6)
• EPA Substance Registry System: 4-nitro-2-vinylaniline(107734-23-6)

Safety Data

• Hazardous Substances Data: 107734-23-6(Hazardous Substances Data)

Upstream product

• 13296-94-1 2-bromo-4-nitroaniline 
• 100-01-6 4-nitro-aniline 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 19591-18-5 N-(2-iodo-4-nitrophenyl)acetamide 

Downstream Products

• 29969-57-1 2-chloro-6-nitroquinoline 
• 1395060-04-4 2-iodo-N-methyl-N-(4-nitro-2-vinylphenyl)benzamide 
• 1395060-03-3 2-iodo-N-(4-nitro-2-vinylphenyl)benzamide 

Relevant articles and documents

Pd-tBuONO Cocatalyzed Aerobic Indole Synthesis

A Pd-tBuONO co-catalyzed scalable and practical synthesis of indoles with molecular oxygen as terminal oxidant is developed. Either terminal or internal 2-vinylanilines could be smoothly converted to desired indoles under one general condition. This method has been evaluated in the large scale synthesis of indomethacin and a potential anti-breast cancer drug candidate 1. (Figure presented.).

Novel synthesis of 2-chloroquinolines from 2-vinylanilines in nitrile solvent

2-Vinyl- or heteroaryl-substituted anilines were reacted with diphosgene in acetonitrile solution via a reactive imidoyl moiety to afford the corresponding 2-chloroquinolines. Facile syntheses of nine 2-chloroquinoline derivatives from several anilines and their postulate mechanism is described. The postulate mechanism of 2-chloroquinoline formation via imidoyl moiety as a good leaving group shows that the reaction consists of the following three steps: (1) generation of phenylisocyanate, (2) quinoline ring formation, and (3) chlorination on C2 position of quinoline.