19591-18-5

Basic information

• Product Name: N-(2-iodo-4-nitrophenyl)acetamide
• CAS NO: 19591-18-5
• Molecular Formula: C₈H₇IN₂O₃
• Molecular Weight: 306.0573
• Mol File: 19591-18-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 448.7°C at 760 mmHg
• Flash Point: 225.2°C
• Density: 1.956g/cm³
• Vapor Pressure: 3.04E-08mmHg at 25°C
• Refractive Index: 1.692
• CAS DataBase Reference: N-(2-iodo-4-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-iodo-4-nitrophenyl)acetamide(19591-18-5)
• EPA Substance Registry System: N-(2-iodo-4-nitrophenyl)acetamide(19591-18-5)

Safety Data

• Hazardous Substances Data: 19591-18-5(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 6293-83-0 2-iodo-4-nitrophenylamine 
• 75-36-5 acetyl chloride 
• 142-71-2 copper diacetate 
• 64-19-7 acetic acid 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 1030373-73-9 N-(2-allyl-4-nitrophenyl)acetamide 
• 2941-63-1 2-methyl-6-nitrobenzothiazole 
• 3507-21-9 N,N-dimethyl-6-nitrobenzo[d]thiazol-2-amine 
• 476429-81-9 2-(furan-2-yl)-4-nitroaniline 
• 107734-23-6 4-nitro-2-vinylaniline 
• 29969-57-1 2-chloro-6-nitroquinoline 

Relevant articles and documents

PtCl4-catalyzed cyclization of N-acetyl-2-alkynylanilines: A mild and efficient synthesis of N-acetyl-2-substituted indoles

An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramolecular hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1–2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates.

Monoprotected l-Amino Acid (l-MPAA), Accelerated Bromination, Chlorination, and Iodination of C(sp2)?H Bonds by Iridium(III) Catalysis

Halogenated arenes are important structural motifs commonly found in biologically active molecules and used for a variety of transformations in organic synthesis. Herein, we report the mono-protected l-amino acid (l-MPAA) accelerated iridium(III)-catalyzed halogenation of (hetero)anilides at room temperature. This reaction constitutes the first example of an iridium(III)/l-MPAA-catalyzed general halogenation of (hetero)arenes through C(sp2)?H activation. Furthermore, we demonstrate the potential utility of our method through its use in the synthesis of a quinolone derivative.

Synthesis of 2,3-Disubstituted Indoles and Benzofurans by the Tandem Reaction of Rhodium(II)-Catalyzed Intramolecular C-H Insertion and Oxygen-Mediated Oxidation

A highly effective and straightforward method to construct a wide range of functionalized 2,3-disubstituted indoles has been developed. The method involves the tandem reaction of rhodium(II)-catalyzed denitrogenative annulation of triazole-based benzyl an