107740-73-8

Upstream product

• 299-42-3 ephedrine 

Downstream Products

• 88563-99-9 (S)-N-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-phenyl-butyramide 
• 88563-99-9 (R)-N-((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-phenyl-butyramide 
• 178614-18-1 (S)-3-Methyl-pentanoic acid ((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 

Relevant academic research and scientific papers

A FACILE ASYMMETRIC SYNTHESIS OF β-SUBSTITUTED ALKANOIC ACID. THE HIGHLY STEREOSELECTIVE MICHAEL ADDITION OF GRIGNARD REAGENTS TO α,β-UNSATURATED CARBOXYLIC AMIDES DERIVED FROM L-EPHEDRINE

The Michael addition of Grignard reagents to chiral α,β-unsaturated carboxylic amides derived from l-ephedrine affords highly optically active β-substituted alkanoic acids after acid hydrolysis.This high stereoselectivity is explained by considering the formation of rigid internal chelate complexes.