88563-99-9

Basic information

• Product Name: (S)-N-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-phenyl-butyramide
• Synonyms: (S)-N-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-phenyl-butyramide
• CAS NO: 88563-99-9
• Molecular Weight: 311.424
• Mol File: 88563-99-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-N-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-phenyl-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-phenyl-butyramide(88563-99-9)
• EPA Substance Registry System: (S)-N-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-phenyl-butyramide(88563-99-9)

Safety Data

• Hazardous Substances Data: 88563-99-9(Hazardous Substances Data)

Upstream product

• 79164-28-6 N-crotonyl-(+)-ephedrin 
• 100-58-3 phenylmagnesium bromide 
• 107740-73-8 N-crotonyl-(-)-ephedrine 
• 299-42-3 ephedrine 
• 591-51-5 phenyllithium 
• 678991-32-7 E-(+)-(1'S,2'S)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)but-2-enamide 

Downstream Products

• 2031-46-1 (R)-3-phenylbutanol 
• 772-14-5 (R)-3-phenylbutyric acid 
• 88564-08-3 Trifluoro-acetic acid (R)-1-((R)-3-phenyl-butyl)-1-(2,2,2-trifluoro-acetoxymethyl)-decyl ester 
• 88564-02-7 (2R,5R)-2-Phenyl-5-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-tetradecan-5-ol 
• 88564-04-9 (R)-2-((R)-3-Phenyl-butyl)-undecane-1,2-diol 
• 88564-07-2 Trifluoro-acetic acid (S)-1-((R)-3-phenyl-butyl)-1-(2,2,2-trifluoro-acetoxymethyl)-decyl ester 
• 88564-02-7 (2R,5S)-2-Phenyl-5-((2S,4aR,7R,8aS)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-tetradecan-5-ol 
• 88564-03-8 (S)-2-((R)-3-Phenyl-butyl)-undecane-1,2-diol 
• 27798-98-7 (-)(R)-4-bromo-2-phenyl-butane 
• 4593-90-2 (S)-2-phenylbutanoic acid 
• 88564-09-4 Trifluoro-acetic acid (S)-1-((S)-3-phenyl-butyl)-1-(2,2,2-trifluoro-acetoxymethyl)-decyl ester 
• 88564-10-7 Trifluoro-acetic acid (R)-1-((S)-3-phenyl-butyl)-1-(2,2,2-trifluoro-acetoxymethyl)-decyl ester 
• 88564-02-7 (2S,5R)-2-Phenyl-5-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-tetradecan-5-ol 
• 88564-02-7 (2S,5S)-2-Phenyl-5-((2S,4aR,7R,8aS)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-tetradecan-5-ol 

Relevant articles and documents

(S,S)-(+)-pseudoephedrine as chiral auxiliary in asymmetric conjugate addition and tandem conjugate addition/α-alkylation reactions

(Chemical Equation Presented) Organolithium reagents undergo highly regio- and diastereoselective 1,4-addition to (S,S)-(+)-pseudoephedrine enamides furnishing the corresponding β-alkyl-substituted adducts in excellent yields and diastereoselectivities. In addition, the intermediate lithium enolates generated after the conjugate addition step undergo a highly diastereoselective alkylation reaction, furnishing α,β-dialkyl- substituted amides in high yields. The obtained adducts have been converted into chiral nonracemic β-alkyl- and α,β-dialkyl-substituted carboxylic acids and γ-alkyl- and β,γ-dialkyl-substituted alcohols using very simple and high-yielding procedures.

A convergent asymmetric synthesis of (-)-malyngolide and its three stereoisomers

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