107776-24-9

Upstream product

• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 766-51-8 2-Chloroanisole 

Downstream Products

• 1026551-26-7 4-[(6-Chloro-7-isopropoxy-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-hydroxy-methyl]-benzoic acid methyl ester 
• 1026947-44-3 4-(3-Chloro-4-methoxy-phenyl)-butyryl chloride 
• 854432-88-5 4-(3-chloro-4-methoxy-phenyl)-butyric acid 
• 169300-49-6 6-chloro-7-methoxy-3,4-dihydro-2H-naphthalen-1-one 
• 103857-53-0 5-(3-chloro-4-methoxy-phenyl)-dihydro-furan-2-one 
• 39496-87-2 4-(3-chloro-4-methoxyphenyl)-4-oxobutanoic acid 

Relevant academic research and scientific papers

A novel type of retinoic acid receptor antagonist: Synthesis and structure-activity relationships of heterocyclic ring-containing benzoic acid derivatives

A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans- retinoic acid were evaluated by in vitro assay systems using human promyelocytic leukemia (HL-60) cells. Structure-activity relationships indicated that both an N-substituted pyrrole or pyrazole (1-position) and a hydrophobic region, with these linked by a ring system, were indispensable for effective antagonism. Among the compounds evaluated, optimal antagonism was exhibited by 4-[4,5,7,8,9,10-hexahydro-7,7,10,-10-tetramethyl-1-(3- pyridylmethyl)anthra[1,2-b]pyrrol-3-yl]benzoic acid (31), 4-[4,5,7,8,9,10- hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)-5-thiaanthra[1,2- b]pyrrol-3-yl]benzoic acid (40), and 4-[4,5,7,8,9,10-hexahydro-7,7,10,10- tetramethyl-1-(3-pyridylmethyl)anthra[2,1-d]pyrazol-3-yl]benzoic acid (55), all of which possess a 3-pyridylmethyl group at the five-membered ring nitrogen atom.