107776-87-4Relevant academic research and scientific papers
Synthesis of nitrogen heterocycles by the ring opening of pyridinium salts
Kearney, Aaron M.,Vanderwal, Christopher D.
, p. 7803 - 7806 (2007/10/03)
(Chemical Equation Presented) The century-old ring-opening reaction of pyridinium salts with tethered nucleophiles has been harnessed for a synthesis of substituted indoles and related nitrogen heterocyles. Extension of this method could lead to oxygen- and sulfur-containing heterocycles and carbocycles, as well as to applications in natural product synthesis and medicinal chemistry.
Direct Coupling of Functionalized Organolithium Compounds with Aryl and Vinyl Halides
Barluenga, Jose,Montserrat, Javier M.,Florez, Josefa
, p. 5976 - 5980 (2007/10/02)
The reaction between β- and γ-nitrogen-functionalized and γ- and ε-oxygen-functionalized organolithium compounds 3, 4, 30-32 and different aromatic, heteroaromatic, and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 5-26 and alcohols 33-37.Symmetrical and mixed products of double coupling 38-40 were also prepared from 1,4-diiodobenzene.The formation of alkyl halides as intermediates has been verified.Aryl or vinyl halides giving rise to unstable aryl or vinyllithium reagents were unsuccessful in the coupling reaction.
