1078154-41-2Relevant academic research and scientific papers
2-ALKOXYESTRADIOL ANALOGS AND PHARMACEUTICAL PREPARATIONS
-
Page/Page column 32, (2009/01/20)
Novel 2-alkoxyestradiol analogs, pharmaceutical compositions and methods of treatment of proliferative and angiogenesis associated conditions are disclosed.
Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs-Part II
Rao, Pemmaraju N.,Cessac, James W.,Boyd, James W.,Hanson, Arthur D.,Shah, Jamshed
, p. 158 - 170 (2008/03/18)
The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior biological activities compared to 2-methoxyestradiol. The relationship between biological activity and the conformational preference of the 13-ethyl group as determined by computational analysis is discussed.
