937-14-4

Basic information

• Product Name: 3-Chloroperoxybenzoic acid
• Synonyms: 3-CHLOROPERBENZOIC ACID;3-CHLOROPEROXYBENZOIC ACID;3-Chloroperoxy benzoic acid(more than 57% but not more than 86%,with 3-chorobenzoic acid);M-CPBA;M-CHLOROPERBENZOIC ACID;M-CHLOROPEROXYBENZOIC ACID;M-CHLORO BENZOYL HYDROPEROXIDE;3-Chlorobenzenecarboperoxoic acid
• CAS NO: 937-14-4
• Molecular Formula: C₇H₅ClO₃
• Molecular Weight: 172.57
• EINECS: 213-322-3
• Product Categories: PHARMACEUTICAL INTERMEDIATES;Organic acids;Organic Peroxide;Oxidation;Synthetic Organic Chemistry;Aromatics
• Mol File: 937-14-4.mol
• Article Data: 22

Chemical Properties

• Melting Point: 69-71 °C(lit.)
• Boiling Point: 244.67°C (rough estimate)
• Flash Point: 138.6 °C
• Appearance: White/Moist Powder
• Density: 0.56
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.4580 (estimate)
• Storage Temp.: 2-8°C
• PKA: 7.57 (in water @ 25 °C)
• Water Solubility: insoluble
• Stability: Strong oxidizing agent - contact with combustible material may cause fire. May be shock or heat sensitive. Incompatible with org
• BRN: 608317
• CAS DataBase Reference: 3-Chloroperoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloroperoxybenzoic acid(937-14-4)
• EPA Substance Registry System: 3-Chloroperoxybenzoic acid(937-14-4)

Safety Data

• Hazard Codes: O,Xi,C
• Statements: 5-8-36/37/38-43-7-34-22
• Safety Statements: 17-26-36/37-45-36/37/39-3/7-14-27-7/9
• RIDADR: UN 3106 5.2
• WGK Germany: 3
• RTECS: SD9470000
• F: 4.4
• TSCA: Yes
• HazardClass: 5.2
• PackingGroup: II
• Hazardous Substances Data: 937-14-4(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 937-14-4 differently. You can refer to the following data:
1. 3-chloroperoxybenzoic acid is white powdery crystals. Melting point is 92-94°C (decomposed). It is almost insoluble in water, but soluble in ethanol, ethers, chloroform, and dichloroethane. It is thermally stable and has an annual decomposition rate of less than 1% at room temperature. The decomposition rate is accelerated in the liquid state. 3-Chloroperbenzoic acid is sensitive to heat and shock, and pure solid. 3-Chloroperbenzoic acid is flammable and potentially explosive. It contains a weak –O–O– bond and a nucleophilic OH group, that makes it versatile oxidative and easily breakable.
2. White moist powder

Uses

Different sources of media describe the Uses of 937-14-4 differently. You can refer to the following data:
1. 3-Chloroperoxybenzoic acid is commonly used in double bond epoxidation, nitridation, cyclization, Baeyer-Villiger oxidation, and N-oxidation. It can also be used as an oxidant for fine chemicals such as synthetic medicine and pesticides. It is also sometimes used as a bleaching agent [1-6]. ? Used in cyclization reaction, Baeyer-Villiger reaction, N-oxidation reaction and S-oxidation reaction. ? Used as an oxidant for fine chemical products such as synthetic medicine and pesticides. ? Used as oxidant and bleach. ? As a good electrophilic reagent, it can react with many functional groups and can oxidize olefins, enol silyl ethers, furans, sulfides, selenides and amino compounds.
2. 3-Chloroperoxybenzoic acid is a strong oxidizing agent used in the oxidation reactions such as aldehydes and ketones to esters (Bayer-Villiger-Oxidation), olefines to epoxides, sulfides to sulfoxides and sulfones, and amines to nitroalkanes, N-oxides.
3. Effective oxidant for epoxidizing di-, tri-, and tetra-substituted olefins.

Reactions

3-Chloroperoxybenzoic acid (MCPBA) is one of the most popular oxidation reagent in organic synthesis, because of its outstanding performance in terms of: reactivity, combined with reducing the number of reaction steps in classical synthetic routes, regio- and stereoselectivity, protection of functional groups mostly not required, high purity and yields. Its literature covers a huge area of different syntheses and below reaction equations just can be a brief overview of its interesting applications:

Synthesis Reference(s)

Synthetic Communications, 19, p. 1271, 1989 DOI: 10.1080/00397918908054534

General Description

3-Chloroperoxybenzoic acid is sensitive to heat. Storage of 3-Chloroperoxybenzoic acid must be done so with stringent temperature control measures. It's explosion hazard is also mitigated by mixing the peroxide in a solvent slurry.

Reactivity Profile

May explode from heat, shock, friction or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames.

Purification Methods

Recrystallise MCPBA from CH2Cl2 [Traylor & Mikztal J Am Chem Soc 109 2770 1987]. Peracid of 99+% purity can be obtained by washing commercial 85% material with phosphate buffer pH 7.5 and drying the residue under reduced pressure. Alternatively the peracid can be freed from m-chlorobenzoic acid by dissolving 50g/L of *benzene and washing with an aqueous solution buffered at pH 7.4 (NaH2PO4/NaOH) (5 x 100mL). The organic layer is dried over MgSO4 and carefully evaporated under vacuum. Necessary care should be taken in case of EXPLOSION. The solid is recrystallised twice from CH2Cl2/Et2O and stored at 0o in a plastic container as glass catalyses the decomposition of the peracid. The acid is assayed iodometrically. [Schwartz & Blumbrgs J Org Chem 29 1976 1964, Bortolini et al. J Org Chem 52 5093 1987, McDonald et al. Org Synth Coll Vol VI 276 1988, Beilstein 9 IV 972.]

InChI:InChI:1S/C7H5ClO3/c8-6-3-1-2-5(4-6)7(9)11-10/h1-4,10H

Synthetic route

3-chlorobenzamide (618-48-4) → 3-chloro-benzenecarboperoxoic acid (937-14-4)

Conditions	Yield
Stage #1: 3-chlorobenzamide With sodium nitrite; N-bromoacetamide at 16℃; for 2.16667h; Stage #2: With zinc fluoride; water for 4h; Temperature;	98.7%

m-Chlorobenzoyl chloride (618-46-2) → 3-chloro-benzenecarboperoxoic acid (937-14-4)

Conditions	Yield
With potassium hydroxide; 1-hydroxyethylene-(1,1-diphosphonic acid); dihydrogen peroxide In methanol; water at 17 - 18℃; Product distribution; dependence of the purity of the product on the ratio of the solvent components, m-CBC:KOH and m-CBC:H2O2 ratios, stirring rates, nature and concentration of phosphorus-containing stabilizers and reactions temperatures;	88%
With potassium hydroxide; 1-hydroxyethylene-(1,1-diphosphonic acid); dihydrogen peroxide In ethanol; water at 20℃; Product distribution; effect of the solvent ratio and amount, the stabilizer;
With potassium hydroxide; 1-hydroxyethylene-(1,1-diphosphonic acid); dihydrogen peroxide In methanol; chloroform; water at 20℃; preparation of highly concentrated m-chloroperoxybenzoic acid;
With hydrogenchloride; potassium hydroxide; 1-hydroxyethylene-(1,1-diphosphonic acid); dihydrogen peroxide 1.) water, ethanol, 17-20 degC; 2.) chloroform, -5 degC, pH=2; Yield given. Multistep reaction;
With magnesium sulfate heptahydrate; dihydrogen peroxide; potassium hydroxide In 1,4-dioxane; water at 15 - 20℃; for 0.333333h;

3-chlorobenzoate (535-80-8) → 3-chloro-benzenecarboperoxoic acid (937-14-4)

Conditions	Yield
With potassium peroxomonosulphate; N-benzyl-N,N,N-triethylammonium chloride In diethyl ether; water at 20℃; for 15h;	87.5%
With dihydrogen peroxide In dichloromethane at 10℃; for 15h; Yield given;
With potassium permanganate; benzyltriphenylphosphonium chloride In chloroform; water at 15℃; for 8h; Reagent/catalyst; Temperature; Solvent;

4-Bromothiophen-2-aldehyde (18791-75-8) + Dimethyldisulphide (624-92-0) → 4-(methylsulfanyl)thiophene-2-carbaldehyde (222554-16-7) + 3-chloro-benzenecarboperoxoic acid (937-14-4)

3-Chlorobenzaldehyde (587-04-2) → 3-chloro-benzenecarboperoxoic acid (937-14-4)

Conditions	Yield
With oxygen In 1,2-dichloro-ethane at 20℃; Reagent/catalyst;

3-chloro-benzenecarboperoxoic acid (937-14-4) + (1S,5S,7S)-3-[(E)-2-methyl-2-pentenyl]-7-exo-hydroxymethyl-6,8-dioxa-3-azabicyclo[3.2.1]octane → 3-Chloro-benzoate(1S,3S,5S,7S)-3-hydroxy-7-hydroxymethyl-3-((E)-2-methyl-pent-2-enyl)-6,8-dioxa-3-azonia-bicyclo[3.2.1]octane;

Conditions	Yield
In dichloromethane at 0 - 20℃; for 2h; Oxidation;	100%

3-chloro-benzenecarboperoxoic acid (937-14-4) + methyl (1S,5S,7R)-3-cinnamyl-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-exo-carboxylate → 3-Chloro-benzoate(1S,3S,5S,7R)-3-hydroxy-7-methoxycarbonyl-3-((E)-3-phenyl-allyl)-6,8-dioxa-3-azonia-bicyclo[3.2.1]octane;

Conditions	Yield
In dichloromethane at 0 - 20℃; for 2h; Oxidation;	100%

3-chloro-benzenecarboperoxoic acid (937-14-4) + (1S,5S,7S)-3-cinnamyl-6,8-dioxa-7-exo-hydroxymethyl-3-azabicyclo[3.2.1]octane → 3-Chloro-benzoate(1S,3S,5S,7S)-3-hydroxy-7-hydroxymethyl-3-((E)-3-phenyl-allyl)-6,8-dioxa-3-azonia-bicyclo[3.2.1]octane;

Conditions	Yield
In dichloromethane at 0 - 20℃; for 2h; Oxidation;	100%

3-chloro-benzenecarboperoxoic acid (937-14-4) + (1S,4R,5S,7S)-3-[(E)-2-methyl-2-pentenyl]-4-exo-benzyl-7-endo-hydroxymethyl-6,8-dioxa-3-azabicyclo[3.2.1]octane → 3-Chloro-benzoate(1S,3S,4R,5S,7S)-4-benzyl-3-hydroxy-7-hydroxymethyl-3-((E)-2-methyl-pent-2-enyl)-6,8-dioxa-3-azonia-bicyclo[3.2.1]octane;

Conditions	Yield
In dichloromethane at 0 - 20℃; for 2h; Oxidation;	100%

3-chloro-benzenecarboperoxoic acid (937-14-4) + (1S,4R,5S,7S)-3-cinnamyl-4-endo-benzyl-6,8-dioxa-7-exo-hydroxymethyl-3-azabicyclo[3.2.1]octane → 3-Chloro-benzoate(1S,3S,4R,5S,7S)-4-benzyl-3-hydroxy-7-hydroxymethyl-3-((E)-3-phenyl-allyl)-6,8-dioxa-3-azonia-bicyclo[3.2.1]octane;

Conditions	Yield
In dichloromethane at 0 - 20℃; for 2h; Oxidation;	100%

3-chloro-benzenecarboperoxoic acid (937-14-4) + (S,E)-N(3)-(3',3'-dimethyl-but-1'-enyl)-4-phenyl-5,5-dimethyloxazolidin-2-one (636580-96-6) → (4S,1'R,2'S)-N(3)-(1'-m-chlorobenzoyl-2'-hydroxy-3',3'-dimethyl-but-1'-yl)-4-phenyl-5,5-dimethyloxazolidin-2-one (636580-99-9)

Conditions	Yield
In chloroform at 0 - 20℃;	100%
In chloroform at 0 - 20℃;	100%

(4S,2'R,3'S)-N(3)-(3'-methyloxiran-2'-yl)-4-phenyl-5,5-dimethyloxazolidin-2-one (1067232-31-8) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → (4S,1'R,2'S)-N(3)-[1'-(m-chlorobenzoyl)-2'-hydroxy-propan-1'-yl]-4-phenyl-5,5-dimethyloxazolidin-2-one (1067232-34-1)

Conditions	Yield
In acetone at 0 - 20℃;	100%

t-butyl [(1S)-1-({4-[(4-fluorophenyl)thio]piperidin-1-yl}carbonyl)-2-methylpropyl]carbamate (1189550-39-7) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → t-butyl [(1S)-1-({4-[(4-fluorophenyl)sulfonyl]piperidin-1-yl}carbonyl)-2-methylpropyl]carbamate (1189550-40-0)

Conditions	Yield
In dichloromethane at 20℃; for 1h;	100%

3,4-dihydro-2H-pyran (110-87-2) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 3-hydroxytetrahydro-2H-pyran-2-yl 3-chlorobenzoate (1334610-35-3)

Conditions	Yield
In dichloromethane at 0℃; for 1h;	100%

C52H84B2Br6N12Ni2O2 + 3-chloro-benzenecarboperoxoic acid (937-14-4) → [NiII(OOC(=O)C6H4Cl-m)(TpiPr2,Br)]

Conditions	Yield
In diethyl ether at -40.16℃; for 0.166667h; Inert atmosphere; Schlenk technique;	100%

C17H19Cl(56)FeN5O4(2-)*2C8H20N(1+) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → C17H19(57)FeN5O5(1-)*2C8H20N(1+)

Conditions	Yield
Cooling;	100%

3-chloro-benzenecarboperoxoic acid (937-14-4) + 4-chloro-7-azaindole (55052-28-3) → 4-chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide 3-chlorobenzoic acid salt (935466-76-5)

Conditions	Yield
In ethyl acetate at 0℃; for 2h;	100%
In n-heptane; acetic acid butyl ester at 0 - 20℃; for 12h;	94%
In n-heptane; acetic acid butyl ester at 0 - 20℃;	94%
In n-heptane; acetic acid butyl ester at 0 - 20℃; for 12h;	94%
In n-heptane; acetic acid butyl ester at 20℃;	75%

3-[5-(4-toluyl)-1,3,4-oxadiazol-2-yl]-10-methylphenothiazine + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 3-[5-(4-toluyl)-1,3,4-oxadiazol-2-yl]-10-methylphenothiazine-S,S-dioxide

Conditions	Yield
With pyridine In dichloromethane	99.3%

methyl 2-({2-[4-(benzyloxy)phenyl]ethyl}thio)-3-[4-(2-{4-[(methylsulfonyl)oxy]-phenoxy}ethyl)phenyl]propanoate (549494-37-3) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → methyl 2-((2-[4-(benzyloxy)phenyl]ethyl)sulfonyl)-3-[4-(2-(4-[(methylsulfonyl)oxy]phenoxy)ethyl)phenyl]propanoate (817642-93-6)

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane at 20℃; for 2h;	99%

(RS,SR)-(η5-C5H5)Fe(CO)(PPh3)(COCH(Me)SPh) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → (RSS,SRR)-(η5-C5H5)Fe(CO)(PPh3)(COCH(Me)SOPh)

Conditions	Yield
-100°C; X-ray diffraction;	99%

Ru(C20H8N4(C6H3(OCH2)2C3H2O2(C6H5)2)4)(CO) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → Ru(C20H8N4(C6H3(OCH2)2C3H2O2(C6H5)2)4)(O)2

Conditions	Yield
according to Groves et al., J. Am. Chem. Soc. 1985, 107, 5790; 1988, 110, 4217;	99%

5,6-dihydropyridine-1(2H)-carboxylate (174681-58-4) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 3,4-epoxy-piperidine-1-carboxylic acid benzyl ester (66207-08-7)

Conditions	Yield
In dichloromethane at 0 - 20℃;	99%

6-iodoquinoline (13327-31-6) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → C9H8INO

Conditions	Yield
With potassium carbonate In chloroform at 20℃; for 48h;	99%

[Ru(2,2’-bipyridine)2((2-(methylthio)phenyl)bis(4-methoxyphenyl)phosphane)](PF6)2 + 3-chloro-benzenecarboperoxoic acid (937-14-4) → [Ru(2,2’-bipyridine)2(p-MeOPh2-PSO-Me)](PF6)2

Conditions	Yield
In acetonitrile at 20℃; for 12h; Inert atmosphere; Schlenk technique;	99%

N-methyl-N-(naphthalen-2-ylethynyl)methanesulfonamide + 3-chloro-benzenecarboperoxoic acid (937-14-4) → C21H18ClNO5S

Conditions	Yield
In 1,2-dichloro-ethane at 20℃; for 2h;	99%

cyclopentadienyltricarbonyl(4-methylbenzenethiolato)tungsten(II) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → (C5H5)W(CO)3SO2(p-C6H4CH3)

Conditions	Yield
With ammonia In dichloromethane ClC6H4CO3H was added to a CH2Cl2 soln. of CpW(CO)3SPh, mixt. stirred moderately for 1 h, react. was monitored by IR; to remove unreacted educt and byproduct anhydrous ammonia was bubbled into the soln., ppt. was filtered, soln. was evapd.; IR, NMR;	98%

(η5-C5H4Si(CH3)3)2Ti(CCSi(CH3)3)2CuCH3 + 3-chloro-benzenecarboperoxoic acid (937-14-4) → [((η(5)C5H4SiMe3)2Ti)(CCSiMe3)2]CuOOC(O)C6H4Cl-3

Conditions	Yield
In tetrahydrofuran byproducts: CH4; all manipulations in atm. of purified N2; org. compd. added to Ti compd. in THF at -70°C; volatiles removed in vac., residue washed with cold n-pentane, elem. anal.;	98%

(η5:η1-C5H4CH2CH2N(Me)CH2CH2CH2CH2OH)Re(CO)2 (676544-27-7) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → (η5:η1-C5H4CH2CH2N(Me)(CH2)4OH)Re(CO)(η2-CO2)

Conditions	Yield
In dichloromethane MCPBA was added at 0°C to a stirred soln. of Re-complex, the mixt. was stirred for 20 min; the mixt. of the anti- and syn-isomers in 72:28 ratio was formed; evapd., residue was wahsed with Et2O; elem. anal.;	98%

1-carboxybenzyl-3-pyrrolidine (31970-04-4) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → benzyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate (31865-25-5)

Conditions	Yield
In dichloromethane at 20℃; for 18h;	98%

3-fluoro-5-((7-(methylthio)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 3-fluoro-5-((7-(methylsulfoxide)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

Conditions	Yield
In dichloromethane Cooling with ice;	98%

3-chloro-benzenecarboperoxoic acid (937-14-4) + 3-bromo-6-((4-methoxybenzyl)oxy)benzaldehyde (325457-67-8) → 5-bromo-2-((4-methoxybenzyl)oxy)phenol

Conditions	Yield
Stage #1: 3-chloro-benzenecarboperoxoic acid; 3-bromo-6-((4-methoxybenzyl)oxy)benzaldehyde In dichloromethane for 16h; Stage #2: With sodium hydroxide In methanol for 0.5h;	98%

3-chloro-benzenecarboperoxoic acid (937-14-4) → 3-chlorobenzoate (535-80-8)

Conditions	Yield
With 2,3-dicarboxyanthraquinone; oxygen In methanol for 24h; Irradiation;	97%
With KO2 Mechanism;	95%
With 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecin; superoxide Mechanism; Product distribution; further reagent: superoxide, H2O;	95%

3-chloro-benzenecarboperoxoic acid (937-14-4) + 6--N-methylamino>coumarin (1027219-00-6) → 1-(3-chlorobenzoyloxymethyl)-2-(4-chlorophenoxymethyl)-3-methyl-3,7-dihydropyrano<3,2-e>indol-7-one (162130-82-7)

Conditions	Yield
In dichloromethane for 12h; Ambient temperature;	97%

7-Azaindole (271-63-6) + 3-chloro-benzenecarboperoxoic acid (937-14-4) → 1H-pyrrolo[2,3-b]pyridine 1-oxide meta-chlorobenzoic acid salt

Conditions	Yield
In 1,2-dimethoxyethane; n-heptane at 20℃; for 19h; Inert atmosphere;	97%
In diethyl ether at 20℃; for 5h;	96%
In diethyl ether at 20℃; Solvent;	96%

Upstream product

• 535-80-8 3-chlorobenzoate 
• 618-48-4 3-chlorobenzamide 
• 587-04-2 m-Chlorobenzaldehyde 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 624-92-0 Dimethyldisulphide 
• 618-46-2 m-Chlorobenzoyl chloride 

Downstream Products

• 118527-25-6 N,N-dimethyl-4-(phenyl-trans-azo)-aniline-N-oxide 
• 25064-73-7 m-Chlorbenzoyl-isobutyrylperoxid 
• 29558-67-6 α-Chlorpropionyl-m-chlorbenzoylperoxid 
• 122897-81-8 3-Chloro-benzoic acid (2S,3R)-3-bromo-tetrahydro-pyran-2-yl ester 
• 74420-18-1 7-Hydroxy-1H-pyrrolo<2,3-b>pyridinium m-chlorobenzoate 
• 66824-95-1 ethyl 2-(3-chlorobenzamido)acetate 
• 110918-89-3 5-Chloro-6-ethoxy-1,3,5-trimethyl-dihydro-pyrimidine-2,4-dione 
• 100201-55-6 trans-5-chloro-6-hydroxy-1,3-dimethyl-5,6-dihydrothymine 
• 92207-38-0 3-Chloro-benzoic acid (4S,5R)-5-hydroxy-1,3,5-trimethyl-2,6-dioxo-hexahydro-pyrimidin-4-yl ester 
• 42738-99-8 11-hydroxytetrahydrocarbazolenine 
• 78154-49-1 o-phenol 
• 4669-18-5 spiro[cyclopentane-1,2'-indolin]-3'-one 
• 73385-36-1 cis-4-(3-chlorobenzoyloxy)-3-hydroxy-7-methoxy-2,2-dimethylchroman 
• 73385-36-1 trans-4-(3-chlorobenzoyloxy)-3-hydroxy-7-methoxy-2,2-dimethylchroman 

Relevant articles and documents

Method for preparing m-chloroperoxybenzoic acid by utilizing phase transfer catalysis

The invention discloses a method for preparing m-chloroperoxybenzoic acid by utilizing phase transfer catalysis. The method comprises the following steps: dissolving m-chlorobenzoic acid in an organicsolvent, adding an aqueous acidic oxidant solution with a pH value of 1-4, carrying out an oxidation reaction under the action of a phase transfer catalyst, carrying out extraction separation to obtain an organic phase, drying, and separating out filter residues to obtain an organic solution containing m-chloroperoxybenzoic acid. The m-chloroperoxybenzoic acid is obtained by catalyzing the reaction of m-chlorobenzoic acid and an oxidant through the phase transfer catalyst, the raw materials are stable in properties, cheap and easy to obtain, the process is simple and easy to control, the solvent can be recycled, the product yield is high, the yield of the m-chloroperoxybenzoic acid can reach 82% or above, and large-scale industrial production is facilitated.

Synthetic method for drug intermediate m-chloroperbenzoic acid

The invention discloses a synthetic method for the drug intermediate m-chloroperbenzoic acid. The synthetic method comprises the following steps: adding m-chlorophenylacetamide and a sodium nitrate solution into a reaction vessel, controlling a stirring speed to be 230-260 rpm and a solution temperature to be 10-16 DEG C, adding a methyl n-butyl ether solution and a 1,4-butanediol solution, addingN-bromoacetamide in batches within 20-40 min, and continuing a reaction for 60-90 min; and then adding an aqueous solution and zinc fluoride powder, controlling a stirring speed to be 310-330 rpm, continue the reaction for 3-4 h, carrying out washing with a sodium chloride solution for 30-50 min, then carrying out washing with a 3-heptanol solution for 20-40 min, carrying out recrystallization ina nitroethane solution, and then carrying out dehydration with a dehydrating agent so as to obtain the finished m-chloroperoxybenzoic acid.

METHOD FOR PRODUCING AMIDE COMPOUND

Disclosed is a method for producing an amide compound represented by the formula (3) below and having an excellent control activity against a harmful arthropod, which is characterized in that an aniline compound represented by the formula (1) below and an aldehyde compound represented by the formula (2) below are reacted in a solvent in the presence of an oxidizing agent such as oxygen or a peroxide. (In the formulae below, R1, R2 and R3 independently represent a C1-C6 alkyl group which may be substituted by a halogen atom, or the like; and R4, R5, R6 and R7 independently represent a halogen atom or the like.)