1078156-79-2

Upstream product

• 141-97-9 ethyl acetoacetate 
• 299949-24-9 ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 104-87-0 4-methyl-benzaldehyde 
• 57-13-6 urea 

Downstream Products

• 928152-86-7 ethyl 4-methyl-2-(piperidin-1-yl)-6-(p-tolyl)pyrimidine-5-carboxylate 
• 1245716-49-7 ethyl 4-methyl-6-p-tolyl-2-(tosyloxy)pyrimidine-5-carboxylate 
• 1245716-56-6 ethyl 4-methyl-2-morpholino-6-(p-tolyl)pyrimidine-5-carboxylate 
• 1265402-55-8 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetic acid 
• 1265402-49-0 methyl 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate 
• 1265402-43-4 methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate 
• 1265402-37-6 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile 
• 1265402-31-0 4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidine-5-carbaldehyde 
• 1265402-25-2 (4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)methanol 

Relevant academic research and scientific papers

An electrochemical off-on method for pyrimidin-2(1: H)-one synthesis via three-component cyclization

A green and simple 'one-pot' electrochemical off-on approach to synthesize pyrimidin-2(1H)-ones was realized without any catalyst, oxidant and toxic reagent. The desired products were obtained in moderate to good yields after the stepwise 'one-pot' reacti

Microwave-induced one-pot synthesis of pyrimidine-2(1H)-one derivatives as anti-inflammatory agents

A series of pyrimidine-2(1H)-one derivative were obtained by multi-component one-pot synthesis under microwave irradiation. Equimolar quantities of ethylacetoacetate, substituted benzaldehydes and urea undergo condensation followed by cyclizaton in presence of aqueous solution of sodium hydroxide to produce corresponding pyrimidine derivatives. With the help of microwave heating, there is clean reaction with shorter reaction time, environmental-friendly, improved yield as compared to conventional heating method. The structures of the newly synthesized compounds have been established on the basis of their IR, NMR spectral data. These compounds were screened for their anti-inflammatory activity. Some of them were found to possess significant activity as compared to standard drug.

Palladium-catalyzed dehydrogenation of dihydro-heterocycles using isoprene as the hydrogen acceptor without oxidants

An efficient and general method for Pd-catalyzed dehydrogenative aromatization of dihydro-heteroatom compounds without external O2 and H2 is first described. The protocol firstly uses isoprene as a hydrogen acceptor. Various dihydro-

4-Bis(triphenylphosphonium)-2-butene peroxodisulfate as an efficient oxidizing agent for one-pot synthesis of ethyl pyrimidin-2(1H)-one-5-carboxylates

An efficient one-pot synthesis of pyrimidin-2(1H)-ones via three-component condensation of aldehyde, ethyl acetoacetate and urea using 1,4-bis(triphenylphosphonium)-2-butene peroxodisulfate [BTPBPDS] as an oxidant is described.

Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies

Hybrid systems of acridones with substituted pyrimidines were designed with an objective of discovering next generation anticancer agents targeting multiple mechanisms in the cancer cell. Hybrid compounds were synthesized by simple and convenient methods

4-aryl-pyrimidin-2-yl tosylates as efficient reaction partners: Application to the synthesis of pyrimidines functionalised with propargyloxy and 1,2,3-triazolo groups

The 4-arylated pyrimidin-2-yl tosylate derivatives, easily prepared from cheap commercial materials, reacted efficiently with propargyl alcohol/NaOBut to give the corresponding 4-arylated 2-propargyloxy-pyrimidine derivatives which, in a onepot

Palladium(II) catalyzed Suzuki/Sonogashira cross-coupling reactions of sulfonates: An efficient approach to C2-functionalized pyrimidines and pyridines

Pyrimidin-2-yl sulfonates, as a reaction partner, can be easily prepared from inexpensive commercial materials and are efficiently cross-coupled with arylboronic acids and terminal alkynes by using Pd(OAc)2-catalyzed Suzuki and Sonogashira reactions. A wide array of C2-functionalized pyrimidines have been prepared in good to excellent yields. 2-Arylpyridines and 2-(oct-1-ynyl)pyridine were also synthesized. An efficient means to synthesize expanded pyrimidin-2-yl conjugated systems was developed by using Pd(OAc) 2-catalyzed cross-coupling reaction of pyrimidin/pyridin-2-yl sulfonates with arylboronic acids and terminal alkynes. Compared with 2-chloropyrimidines, pyrimidin-2-yl sulfonates can be easily prepared from inexpensive commercial materials and the reactions are more efficient. Copyright

Novel and chemoselective dehydrogenation of 3,4-dihydropyrimidin-2(1h)-ones with 1,4-bis(triphenylphosphonium)-2-butene peroxodisulfate

3,4-Dihydropyrimidin-2(1H)-ones were efficiently converted into the corresponding pyrimidin-2(1H)-ones in high yields within a short period of time on treatment with aqueous acetonitrile using 1,4-bis(triphenylphosphonium)-2- butene peroxodisulfate. Chemo

Free-radical oxidation of 1,2,3,4-tetrahydro-2-oxopyrimidines

Free-radical oxidation of 4-substituted 5-acetyl-and 5-carboethoxy-1,2,3,4- tetrahydro-2-oxopyrimidines using benzoyl peroxide under thermal conditions has been investigated to elucidate the effects of the nature of the substituents in the 4- and 5-positi

An efficient and rapid dehydrogenation of 4-aryl-3,4-dihydropyrimidin-2(1H) -ones (DHPMs) using CAN/HCl

An efficient and operationally simple method for the dehydrogenation of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed using CAN/HCl. 2012 Elsevier Ltd. All rights reserved.