928152-86-7

Upstream product

• 110-89-4 piperidine 
• 1078156-79-2 C₁₅H₁₆N₂O₃ 
• 185023-34-1 5-carboethoxy-6-methyl-4-(4-methylphenyl)-1H-pyrimidin-2-thione 
• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 1078156-79-2 ethyl 1,2-dihydro-6-methyl-2-oxo-4-(4-methylphenyl)pyrimidine-5-carboxylate 
• 299949-24-9 ethyl 6-methyl-2-oxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Downstream Products

• 1265402-55-8 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetic acid 
• 1265402-49-0 methyl 2-tert-butoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate 
• 1265402-43-4 methyl 2-hydroxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)acetate 
• 1265402-37-6 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-2-(trimethylsilyloxy)acetonitrile 
• 1265402-31-0 4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidine-5-carbaldehyde 
• 1265402-25-2 (4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)methanol 

Relevant academic research and scientific papers

Copper(i) chloride promoted Csp2-N cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with amines: An efficient approach to obtain C2-amino functionalized pyrimidines

The copper(i)-promoted cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with aromatic amines and aliphatic amines to deliver C-N coupling products in moderate to good yields is reported in this paper. Central to this strategy is the conversion of disulfides into aryl- and alkyl amines by a copper-promoted chemoselective C-S bond cleavage.

Nucleophilic Substitution Reaction of Pyrimidin-2-yl Phosphates Using Amines and Thiols as Nucleophiles Mediated by PEG-400 as an Environmentally Friendly Solvent

A metal-free synthesis of C2-functionalized pyrimidines via the reaction of pyrimidin-2-yl phosphates with amines and thiophenols in PEG-400 has been developed. The desired products can be generated in good to excellent yields in the environmentally friendly PEG-400, without any catalysts or other additives.

Molecular iodine-mediated S-N and C-N cross-coupling and oxidative aromatization of 3,4-dihydropyrimidin-2(1H)-thiones with secondary amines

A domino S-N and C-N coupling/oxidative aromatization process to synthesize 2-aminothio-phenylpyrimidines and 2-amino-phenylpyrimidines by S-N and C-N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and secondary amines catalyzed by molecular iodine. Remarkably the C-N coupled product was obtained via a desulfitative coupling-aromatization reaction in one-pot reaction.

Synthesis of C2-functionalized pyrimidines from 3,4-dihydropyrimidin-2(1H)- ones by the Mitsunobu coupling reaction

The Biginelli 3,4-dihydropyrimidin-2(1H)-one was converted to various C2-multifunctionalized pyrimidines via the dehydrogenation and Mitsunobu reaction using amines, alcohols, phenols and carboxylic acids as nucleophiles. A possible mechanism was also proposed to rationalize the formation of products.

NOVEL VIRAL REPLICATION INHIBITORS

The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.