107836-64-6Relevant articles and documents
Cobalt-Catalyzed Umpolung Alkylation of Imines to Generate α-Branched Aliphatic Amines
Wan, Li-Qiang,Cao, Jin-Ge,Niu, Dawen,Zhang, Xia
, p. 3818 - 3822 (2021)
Here we report a general and mild approach to prepare α-branched aliphatic amines from imines. This method capitalizes on a cobalt-catalyzed umpolung alkylation of imines, employs easily available reaction partners, and demonstrates a broad substrate scope. Mechanistic studies suggest this transformation occurs by a radical pathway.