107841-61-2Relevant academic research and scientific papers
Reductive Carbocyclization of Homoallylic Alcohols to syn-Cyclobutanes by a Boron-Catalyzed Dual Ring-Closing Pathway
Hazra, Chinmoy Kumar,Jeong, Jinhoon,Kim, Hyunjoong,Baik, Mu-Hyun,Park, Sehoon,Chang, Sukbok
, p. 2692 - 2696 (2018)
The organoborane-catalyzed reductive carbocyclization of homoallylic alcohols has been developed by using hydrosilanes as reducing reagents to provide a range of 1,2-disubstituted arylcyclobutanes. The reaction proceeds in a cis-selective manner with high efficiency under mild conditions. Mechanistic studies, including deuterium scrambling and Hammett studies, and DFT calculations, suggest a dual ring-closing pathway.
