1078719-72-8Relevant academic research and scientific papers
Influence of spacer chain lengths and polar terminal groups on the mesomorphic properties of tethered 5-phenylpyrimidines
Starkulla, Gundula F.,Kapatsina, Elisabeth,Baro, Angelika,Tussetschlaeger, Stefan,Kaller, Martin,Laschat, Sabine,Giesselmann, Frank
experimental part, (2010/04/22)
Based on 5-(4-hydroxyphenyl)-2-octylpyrimidine 8, 5-phenylpyrimidine derivatives 3-9 with different spacer chain lengths (C2 up to C 6) and different terminal polar groups (Br, Cl, N3, OH, CN) were synthesized by etherific
Convergent synthesis of 1,1′-biisoquinolines tethered to calamitic subunits
Kapatsina, Elisabeth,Lordon, Marie,Baro, Angelika,Laschat, Sabine
experimental part, p. 2551 - 2560 (2009/04/07)
A convergent synthesis of a series of 4,4′-functionalized 1,1′-biisoquinolines via 1-chloro-4-hydroxyisoquinoline and substituted biphenyl- and phenylpyrimidine ethers as building blocks is described. The latter were prepared by Williamson etherification of the respective 4-hydroxybiphenyl and -phenylpyrimidine precursors with dibromoalkanes, allowing variation of the spacer lengths. 1-Chloro-4-hydroxyisoquinoline was obtained from N-phthalimidoglycine ethyl ester through a Gabriel-Colman reaction as a key step. Linkage of the building blocks by etherification in the presence of potassium carbonate gave the isoquinolines, which were submitted to a nickel(II) chloride mediated homocoupling to yield the ligand systems. Georg Thieme Verlag Stuttgart.
