1078732-96-3Relevant academic research and scientific papers
A new synthetic approach to (+)-lactacystin based on radical cyclisation of enantiopure α-ethynyl substituted serine derivatives to 4-methylenepyrrolidinones
Pattenden, Gerald,Rescourio, Gwenaella
experimental part, p. 3428 - 3438 (2009/02/05)
Treatment of the acetylenic bromoamide 42c, derived from the enantiopure α-amino alcohol 40, with Bu3SnH-AlBN results in an efficient 5-exo dig radical cyclisation to the 4-methylenepyrrolidinone 43/44 (2: 1). Cleavage of the alkene bond in 43/
