212772-61-7

Upstream product

• 212772-70-8 (2R,3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(2,2-dimethyl-propionyloxymethyl)-1-(4-methoxy-benzyl)-4-methyl-4-methylsulfanyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 1078732-96-3 (5R,4R,3R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-1-(4-methoxybenzyl)-3-methyl-3-methylsulfanyl-2-oxo-pyrrolidine-5-carboxylic acid methyl ester 
• 212772-68-4 (5R,3R)-5-hydroxymethyl-1-(4-methoxybenzyl)-3-methyl-3-methylsulfanyl-2,4-dioxo-pyrrolidine-5-carboxylic acid methyl ester 
• 212772-69-5 (2R,3R,4R)-2-(2,2-Dimethyl-propionyloxymethyl)-3-hydroxy-1-(4-methoxy-benzyl)-4-methyl-4-methylsulfanyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 212772-60-6 (5R,4S,3R)-4-hydroxy-5-hydroxymethyl-1-(4-methoxybenzyl)-3-methyl-3-methylsulfanyl-2-oxo-pyrrolidine-5-carboxylic acid methyl ester 
• 212772-59-3 (R)-1-(4-Methoxy-benzyl)-4-methyl-4-methylsulfanyl-3,5-dioxo-pyrrolidine-2-carboxylic acid methyl ester 
• 20839-80-9 (4-methoxybenzylamino)acetic acid methyl ester 

Downstream Products

• 133343-34-7 Lactacystin 
• 154226-60-5 omuralide 
• 212772-64-0 (2R,3S,4R)-3-Hydroxy-2-((S)-1-hydroxy-2-methyl-propyl)-1-(4-methoxy-benzyl)-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 212772-62-8 (2S,3S,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-formyl-1-(4-methoxy-benzyl)-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 212772-72-0 (2R,3S,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-1-hydroxy-2-methyl-propyl)-1-(4-methoxy-benzyl)-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 212772-63-9 (2R,3S,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((S)-1-hydroxy-2-methyl-allyl)-1-(4-methoxy-benzyl)-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 212772-65-1 (1R,4R,5S)-1-((S)-1-Hydroxy-2-methyl-propyl)-2-(4-methoxy-benzyl)-4-methyl-6-oxa-2-aza-bicyclo[3.2.0]heptane-3,7-dione 

Relevant academic research and scientific papers

A new synthetic approach to (+)-lactacystin based on radical cyclisation of enantiopure α-ethynyl substituted serine derivatives to 4-methylenepyrrolidinones

Treatment of the acetylenic bromoamide 42c, derived from the enantiopure α-amino alcohol 40, with Bu3SnH-AlBN results in an efficient 5-exo dig radical cyclisation to the 4-methylenepyrrolidinone 43/44 (2: 1). Cleavage of the alkene bond in 43/

An efficient and concise enantioselective total synthesis of lactacystin

A selective, irreversible inhibitor of proteasome function, lactacystin (1) is an important experimental tool in cell biology. An efficient and direct enantioselective synthesis of lactacystin proceeds via the intermediates shown below. This process allow