1078735-55-3Relevant academic research and scientific papers
Asymmetric cycloaddition of 1,2-dihydropyridine derivatives in the presence of Lewis acids
Hirama, Masafumi,Kato, Yuji,Seki, Chigusa,Matsuyama, Haruo,Oshikiri, Noriko,Iyoda, Masahiko
supporting information; experimental part, p. 924 - 925 (2009/04/05)
Asymmetric cycloaddition of 1-phenoxycarbonyl- (1) or 1-methoxycarbonyl-1, 2-dihydropyridine (2) with N-acryloyl-(1S)-2,10-camphorsultam (3) produced chiral isoquinuclidine 4a or 5a in good yields with excellent diastereoselectivity in the presence of a Lewis acid such as titanium tetrachloride, zirconium tetrachloride, or hafnium tetrachloride. The absolute stereochemistry assignment of endo-cycloaddition products 4a and 5a has been established to be 1S, 4R, and 7S. Copyright
