107884-32-2

Upstream product

• 64-17-5 ethanol 
• 82419-36-1 ofloxacin 

Downstream Products

• 1315249-12-7 9-fluoro-N'-[(E/Z)-(4-methoxyphenyl)methylidene]-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carbohydrazide 
• 1315249-11-6 N'-[(E/Z)-(2-chlorophenyl)methylidene]-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carbohydrazide 
• 1315249-18-3 6-(4-(3-(4-aminophenyl)-3-oxopropyl)-4,5-dihydro-5-sulfanylene-1,3,4-oxadiazol-2-yl)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-[1,4]oxazino[2,3,4-ij]quinolin-7-one 
• 1315249-17-2 9-fluoro-2,3-dihydro-6-(4,5-dihydro-4-(3-oxo-3-phenylpropyl)-5-sulfanylene-1,3,4-oxadiazol-2-yl)-3-methyl-l,10-(4-methylpiperazin-1-yl)-[1,4]oxazine[2,3,4-ij]quinolin-7-one 
• 1315249-16-1 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-N'-[(E/Z)-phenylmethylidene]-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carbohydrazide 
• 1315249-15-0 9-fluoro-3,7-dihydro-3-methyl-6-(N'-methylene-3-nitrobenzohydrazide) 10-(4-methyl piperazin-1-yl)-2H-[1,4]oxazino[2,3,4-ij]quinolin-7-one 
• 1315249-13-8 9-fluoro-N'-[(E/Z)-(2-hydroxyphenyl)methylidene]-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carbohydrazide 

Relevant academic research and scientific papers

Design, synthesis, and docking studies of novel ofloxacin analogues as antimicrobial agents

A number of novel ofloxacin analogues were synthesized by modifying the carboxylic acid at C-6. To investigate the antimicrobial data on structural basis, in-silico docking studies of the tested compounds into the crystal structure of topoisomerase II using Autodock vina 4.0 program was performed in order to predict the affinity and orientation of the synthesized compounds at the activities. R2 values show good agreement with predicted binding affinities obtained by molecular docking studies. Also, it is verified by in-vitro antimicrobial screening, where all the compounds were most active against Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis. Among these compounds 3a, 3b, 3f showed good MIC (0.125 μg/ml). Springer Science+Business Media, LLC 2011.

Spectroscopic studies on the interaction between Pr(III) complex of an ofloxacin derivative and bovine serum albumin or DNA

The binding properties on [PrL2(NO3)](NO 3)2 (L = 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1- piperaziny)-7-oxo-7Hpyrido[1,2,3-de]-1,4-benzoxazine-6-carbaldehyde benzoyl hydrazone) to bovine serum albumin (BSA

Crystal structure, biological studies of water-soluble rare earth metal complexes with an ofloxacin derivative

Two new water-soluble solid complexes [PrL (NO3) 2(CH3OH)] (NO3), [NdL(NO 3)2(CH3OH)](NO3)(L = 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaziny)-7-ox