1079041-40-9Relevant academic research and scientific papers
Design, synthesis, and antiplasmodial activity of hybrid compounds based on (2 R,3 S)- N-benzoyl-3-phenylisoserine
Njogu, Peter M.,Gut, Jiri,Rosenthal, Philip J.,Chibale, Kelly
supporting information, p. 637 - 641 (2013/07/26)
A series of hybrid compounds based on (2R,3S)-N-benzoyl-3-phenylisoserine, artemisinin, and quinoline moieties was synthesized and tested for in vitro antiplasmodial activity against erythrocytic stages of K1 and W2 strains of Plasmodium falciparum. Two hybrid compounds incorporating (2R,3S)-N-benzoyl-3- phenylisoserine and artemisinin scaffolds were 3- to 4-fold more active than dihydroartemisinin, with nanomolar IC50 values against Plasmodium falciparum K1 strain.
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
Aminake, Makoah N.,Mahajan, Aman,Kumar, Vipan,Hans, Renate,Wiesner, Lubbe,Taylor, Dale,De Kock, Carmen,Grobler, Anne,Smith, Peter J.,Kirschner, Marc,Rethwilm, Axel,Pradel, Gabriele,Chibale, Kelly
, p. 5277 - 5289 (2012/11/07)
Malaria and HIV are among the most important global health problems of our time and together are responsible for approximately 3 million deaths annually. These two diseases overlap in many regions of the world including sub-Saharan Africa, Southeast Asia
