107943-53-3

Upstream product

• 491-78-1 5-Hydroxyflavone 
• 158264-57-4 E-3-phenyl-1-(2-benzoxy-6-hydroxyphenyl)propenone 
• 100-52-7 benzaldehyde 
• 4047-24-9 1-[2-(benzyloxy)-6-hydroxyphenyl]ethanone 
• 59817-25-3 2'-benzyloxy-6'-hydroxychalcone 

Relevant academic research and scientific papers

Syntheses of 5-Hydroxy-2-(phenyl or styryl)chromones and of Some Halo Derivatives

One-pot syntheses of 5-hydroxy-2-(phenyl or styryl)chromones and the corresponding 6- and 8-monoiodo- and 6,8-diiodochromones have been developed. The procedures involve oxidative cyclization of 2′-benzyloxy-6′-hydroxychalcones and 2′-benzyloxy-6′-hydroxy-2-cinnamylideneacetophenones and electrophilic substitution processes on the chromone moieties; such procedures were also applied to the syntheses of 6,8-dibromochromone derivatives.

Synthesis of 6,8-(dibromo or diiodo)-5-hydroxy-2-(phenyl or styryl)chromones

A facile synthetic method has been developed for the preparation of 6,8-(dibromo or diiodo)- -5-hydroxy-2-(phenyl or styryl)chromones. These compounds were obtained by either one-pot synthesis from 2'-benzyloxy-6'-hydroxychalcones or 2'-benzyloxy-6'-hydroxycinnamilydeneacetophenones or from the corresponding 2-phenyl- or 2-styrylchromones.