107968-14-9

Upstream product

• 917-54-4 methyllithium 
• 122428-60-8 α-benzyloxyiminoacetophenone (2S,3S)-1,4-dimethoxy-2,3-butylene acetal 
• 107968-12-7 1-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-ethanol 
• 73611-99-1 2-Hydroxypropiophenone dimethylacetal 
• 50622-10-1 (-)-(2S,3S)-1,4-dimethoxy-2,3-butanediol 

Downstream Products

• 107968-19-4 (R)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-4-trimethylsilanyl-but-3-yn-2-ol 
• 107968-18-3 (S)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-4-trimethylsilanyl-but-3-yn-2-ol 
• 107968-17-2 (R)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-butan-2-ol 
• 107968-16-1 (S)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-butan-2-ol 
• 107968-21-8 (R)-1-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-1-phenyl-ethanol 
• 107968-20-7 (S)-1-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-1-phenyl-ethanol 
• 107968-20-7 1-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-1-phenyl-ethanol 
• 107954-37-0 (S)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-but-3-yn-2-ol 
• 107954-39-2 (R)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-but-3-yn-2-ol 
• 118026-59-8 (S)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-butane-2,3-diol 
• 108031-41-0 (S)-3-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-butane-1,3-diol 
• 107954-36-9 (S)-2-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-propane-1,2-diol 
• 96948-99-1 (R)-(+)-3-methyl-4-phenyl-1,3-butanediol 
• 96948-92-4 (R)-(+)-2-methyl-3-phenyl-1,2-propanediol 

Relevant academic research and scientific papers

Asymmetric Synthesis Using Chiral Acetals: Highly Diastereoselective Addition of Organocerium Reagents to Chiral α-Aldoxime-Ether Acetal

Nucleophilic addition of organometallic reagents to the chiral α-aldoxime-ether acetal (1) was studied.Among the reagents, organocerium reagents showed higher reactivity and stereoselectivity, giving the N-oxygenated chiral amine derivatives (6Aa-c) in a highly diastereoselective manner, whereas Grignard and organolithium reagents afforded no 6.As an application of the reaction, the synthesis of (-)-N-acetylamphetamine (11) was achieved.

Asymmetric Synthesis Using Chiral Acetals: Studies on the Nucleophilic Addition of Organometallics to Chiral α-Keto Acetals in Open-Chain Systems

Nucleophilic addition of organometallic reagents (Grignard reagents and organolithium reagents) to three chiral α-keto acetals (1a-c) in open-chain systems was studied.The reactions of the chiral α-keto acetals (1a,1b) having a chiral auxiliary as a keton

DIASTEREOSELECTIVE NUCLEOPHILIC ADDITION TO CHIRAL OPEN-CHAIN α-KETOACETALS: SYNTHESIS OF (R)- AND (S)-MEVALOLACTONE

Highly stereoselective addition of Grignard reagents to chiral open-chain α-ketoacetals (3a,3b) has been attained.Application of the reaction to syntheses of the key intermediates (6,8) for (R)- and (S)-mevalolactone is also described.