96948-99-1Relevant academic research and scientific papers
Asymmetric Synthesis Using Chiral Acetals: Studies on the Nucleophilic Addition of Organometallics to Chiral α-Keto Acetals in Open-Chain Systems
Tamura, Yasumitsu,Annoura, Hirokazu,Fuji, Masahiro,Yoshida, Takayuki,Takeuchi, Ritsuko,Fujioka, Hiromichi
, p. 4736 - 4746 (2007/10/02)
Nucleophilic addition of organometallic reagents (Grignard reagents and organolithium reagents) to three chiral α-keto acetals (1a-c) in open-chain systems was studied.The reactions of the chiral α-keto acetals (1a,1b) having a chiral auxiliary as a keton
DIASTEREOSELECTIVE NUCLEOPHILIC ADDITION TO CHIRAL OPEN-CHAIN α-KETOACETALS: SYNTHESIS OF (R)- AND (S)-MEVALOLACTONE
Tamura, Yasumitsu,Ko, Tomoko,Kondo, Hiroshi,Annoura, Hirokazu,Fuji, Masahiro,et al.
, p. 2117 - 2120 (2007/10/02)
Highly stereoselective addition of Grignard reagents to chiral open-chain α-ketoacetals (3a,3b) has been attained.Application of the reaction to syntheses of the key intermediates (6,8) for (R)- and (S)-mevalolactone is also described.
ASYMMETRIC SYNTHESES BASED ON HEXAHYDRO-4,4,7-TRIMETHYL-1,3-BENZOXATHIANS
Eliel, Ernest L.
, p. 73 - 96 (2007/10/02)
Earlier work concerned with a highly stereoselective asymmetric synthesis based on a 1,3-oxathiane as the chiral auxiliary reagent is reviewed and recent applications to the synthesis of the four stereoisomers of malyngolide, of (R)-(+)-γ-caprolactone (a
