107971-01-7

Basic information

• Product Name: 1-Methyl-5-phenyl-1,2-dihydro-2-oxopyridine
• Synonyms: 1-Methyl-5-phenyl-1,2-dihydro-2-oxopyridine
• CAS NO: 107971-01-7
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22
• Mol File: 107971-01-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-5-phenyl-1,2-dihydro-2-oxopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-5-phenyl-1,2-dihydro-2-oxopyridine(107971-01-7)
• EPA Substance Registry System: 1-Methyl-5-phenyl-1,2-dihydro-2-oxopyridine(107971-01-7)

Safety Data

• Hazardous Substances Data: 107971-01-7(Hazardous Substances Data)

Usage

Type

Synthetic opioid analgesic and sedative drug

Analog

Oxymorphone

Use

Potent pain-relieving effects

Legal status

Schedule I controlled substance in the United States, not approved for medical use

Mechanism of action

Acts on the central nervous system to produce pain relief and sedation

Potential risks

High potential for abuse and addiction

Function

Binds to opioid receptors in the brain and spinal cord

Perception

Considered a dangerous and highly regulated substance due to its potential for abuse and addiction.

Upstream product

• 1008-88-4 3-phenylpyridine 
• 77-78-1 dimethyl sulfate 
• 694-85-9 1-methyl-2-pyridone 
• 591-50-4 iodobenzene 
• 142-08-5 2-Pyridone 
• 76053-45-7 5-Phenyl-2(1H)-pyridinone 
• 74-88-4 methyl iodide 
• 13466-38-1 5-bromopyridin-2(1H)-one 
• 624-28-2 2,5-dibromopyridine 
• 81971-39-3 5-bromo-1-methylpyridin-2(1H)-one 
• 98-80-6 phenylboronic acid 
• 60684-91-5 iodure de 1-methyl-3-phenylpyridinium 
• 107970-99-0 1,6-dihydro-6-imino-1-methyl-3-phenylpyridine 

Downstream Products

• 128127-15-1 N-phenyl-2-methyl-7-phenyl-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5,6-exo-dicarboximide 
• 128127-15-1 N-phenyl-2-methyl-7-phenyl-3-oxo-2-azabicyclo<2.2.2>oct-7-ene-5,6-endo-dicarboximide 
• 32246-05-2 1-methyl-5-phenyl-piperidin-2-one 

Relevant articles and documents

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt to Synthesize the Indenopyridine Core of Haouamine

An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-arylsubstituted indeno[2,1-b]pyridones, resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described.

Asymmetric Homogeneous Hydrogenation of 2-Pyridones

An asymmetric homogeneous hydrogenation of 2(1H)-pyridones has been developed, using a ruthenium complex bearing two chiral N-heterocyclic carbene (NHC) ligands. To the best of our knowledge, the presented reaction is the first example of a homogeneous asymmetric conversion of 2-pyridones into the corresponding enantioenriched 2-piperidones.