107973-65-9Relevant academic research and scientific papers
Synthesis of polyfunctional imidazoles from vinyl azides and amidine along with NHBoc as a leaving group
Tang, Pai,Ke, Di,Shao,Chen, Wenteng,Yu, Yongping
, p. 4419 - 4424 (2019/07/09)
An efficient method for the synthesis of polyfunctional imidazoles from vinyl azides and amidine has been developed. Starting from vinyl azide and amidine, this transformation proceeds without any additives and the obtained imidazoles can be decorated with ester functional group that is a promising site for further modification.
Safe generation and use of bromine azide under continuous flow conditions-selective 1,2-bromoazidation of olefins
Cantillo, David,Gutmann, Bernhard,Oliver Kappe
supporting information, p. 853 - 857 (2016/01/15)
Bromine azide (BrN3), a useful but extremely toxic and explosive reagent for the preparation of vicinal 1,2-bromine azide compounds, was safely generated and reacted in situ with alkenes in a continuous flow photoreactor. BrN3 was generated by a novel procedure from NaBr and NaN3 in water, and efficiently extracted into an organic phase containing the alkene thus avoiding decomposition. The resulting addition products have been used for the preparation of several useful building blocks.
Synthesis of poly-functionalized imidazoles via vinyl azides annulation
Luo, Jing,Chen, Wenteng,Shao, Jiaan,Liu, Xingyu,Shu, Ke,Tang, Pai,Yu, Yongping
, p. 55808 - 55811 (2015/07/20)
An efficient annulation of vinyl azides with activated imines has been developed for the synthesis of poly-functionalized imidazole derivatives. This reaction includes thermal decomposition of vinyl azides to 2H-azirines, nucleophilic attack of 2H-azirines with activated imines and subsequent cyclization to desired imidazoles.
Reactivity of 2-halo-2H-azirines. Part 3: Dehalogenation of 2-halo-2H-azirine-2-carboxylates
Pinho e Melo, Teresa M. V. D.,Cardoso, Ana L.,Rocha Gonsalves, Anto?nio M. D'A.
, p. 2345 - 2351 (2007/10/03)
The dehalogenation of 2-halo-3-phenyl-2H-azirine-2-carboxylates is described. Using sodium borohydride and tributyltin hydride 3-phenyl-2H-azirine-2-carboxylates were obtained in moderate yields. The synthesis of a new 2-bromo-2H-azirines with a chiral au
