61013-61-4

Upstream product

• 637-81-0 ethyl-2-azidoacetate 
• 100-52-7 benzaldehyde 
• 4192-77-2 ethyl cinnamate 
• 62317-42-4 ethyl 3-acetoxy-2-bromo-3-phenylpropanoate 
• 141-52-6 sodium ethanolate 
• 871-31-8 ethyl azide 
• 71385-43-8 ethyl (25,35)-2-azido-3-hydroxy-3-phenylpropanoate 

Downstream Products

• 81803-56-7 triethyl 2,4,9-triphenyl-1,3,8-triazatricyclo<4.3.0.0^3,5>non-7-ene-5,6,7-tricarboxylate 
• 1795-96-6 phenylalanine ethyl ester 
• 120413-57-2 C₂₉H₂₆NO₂P 
• 3651-13-6 5-methyl-3-phenyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 37129-23-0 ethyl 3-phenyl-1H-indole-2-carboxylate 
• 1108741-87-2 ethyl 7-methoxy-3-phenyl-1H-indole-2-carboxylate 
• 57615-66-4 ethyl 3-phenyl-1H-benzo[g]indole-2-carboxylate 
• 1246775-41-6 ethyl 5,6-dimethyl-3-phenyl-1H-indole-2-carboxylate 
• 40219-04-3 ethyl 7-phenyl-5H-[1,3]dioxolo[4,5-f]indole-6-carboxylate 
• 1203558-67-1 triethyl 5-phenyl-5H-1,2,4-triazole-1,2,3-tricarboxylate 
• 1314185-37-9 3-(furan-2-yl)-1,4-diphenyl-1H-pyrazole-5-carboxylic acid ethyl ester 
• 1314185-39-1 3-(pyridin-2-yl)-1,4-diphenyl-1H-pyrazole-5-carboxylic acid ethyl ester 
• 1314185-46-0 3-isopropyl-1,4-diphenyl-1H-pyrazole-5-carboxylic acid ethyl ester 
• 1314185-34-6 3-(2-bromophenyl)-1,4-diphenyl-1H-pyrazole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

A multi-substituted imidazole derivatives method for the preparation of

The invention provides a preparation method of multifunctional group-substituted imidazole derivatives including derivatives of 2,4,5-trisubstituted imidazole and 2-amino-4,5-disubstituted imidazole, and the derivatives are generated by alkenyl nitrine de

Synthesis of 2,3,4-trisubstituted pyrroles via a facile reaction of vinyl azides and tosylmethyl isocyanide

A facile synthesis of polysubstituted pyrroles from tosylmethyl isocyanide (TOSMIC) and readily synthesized vinyl azides was developed. The reaction proceeded under mild conditions in the presence of base. 2-Tosyl-substituted pyrroles were obtained in moderate to good isolated yields. Additionally, a base-initiated one-pot pyrrole synthesis also was developed using carboxaldehydes, ethyl 2-azidoacetate, and TOSMIC.

Facile synthesis of 2-alkylthio-3-alkyl-5-phenylmethylidene-4H-imidazol-4- ones

2-Alkylthio-3-alkyl-5-phenylmethylidene-4H-imidazol-4-ones 6 were synthesized by N-alkylation and S-alkylation of 2-thioxo-5-phenylmethylidene-4- imidazolidinone 5, which was obtained via cyclization of vinyl isothiocyanate 4 with excess ammonium hydroxid

Synthesis of phenylalanine analogs

A straight forward synthesis of phenylalanine analogs is described. Cerium ammonium nitrate (CAN) mediated addition of azide to cinnamicester, followed by reaction with sodium acetate aff orded the α-azidocinnamate in moderate yield. Hydrogenation of α-azidocinnamate, followed by BOC, CBZ or Fmoc protection gave phenylalanine analogs. A new approach for synthesizing racemic p-boronophenylalanine analog was also explored.

New findings on the hemetsberger-knittel reaction (synthetic studies on indoles and related compounds. XLIII(1))

In the Hemetsberger-Knittel reaction for indole synthesis, the intermediate ethyl 2-azido-3-hydroxy-3-aryl-propionate (4) was found to be formed in the reaction of arylaldehyde 1 with ethyl azidoacetate at a lower temperature (-30°C) as the main product,