107983-40-4

Basic information

• Product Name: 1,3-Dioxolane-4-carboxylicacid,2,2,5-trimethyl-,(4R-trans)-(9CI)
• Synonyms: 1,3-Dioxolane-4-carboxylicacid,2,2,5-trimethyl-,(4R-trans)-(9CI);(4R,5S)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylic acid, (2S,3R)-2,3-O-isopropylidene-2,3-dihydroxybutyric acid, (4R,5S)-2,2,5-Trimethyl-1,3-dioxolan-4-carbonsaeure
• CAS NO: 107983-40-4
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.17
• Product Categories: CARBOXYLICACID
• Mol File: 107983-40-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dioxolane-4-carboxylicacid,2,2,5-trimethyl-,(4R-trans)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane-4-carboxylicacid,2,2,5-trimethyl-,(4R-trans)-(9CI)(107983-40-4)
• EPA Substance Registry System: 1,3-Dioxolane-4-carboxylicacid,2,2,5-trimethyl-,(4R-trans)-(9CI)(107983-40-4)

Safety Data

• Hazardous Substances Data: 107983-40-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Dioxolane-4-carboxylic acid, 2,2,5-trimethyl-, (4R-trans)-(9CI) is used as a starting material for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it suitable for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 1,3-Dioxolane-4-carboxylic acid, 2,2,5-trimethyl-, (4R-trans)-(9CI) serves as a versatile reagent for the preparation of a wide range of organic compounds. Its ability to participate in various chemical reactions, such as esterification, amidation, and condensation, makes it a valuable tool for chemists.
Used in Chemical Research:
1,3-Dioxolane-4-carboxylic acid, 2,2,5-trimethyl-, (4R-trans)-(9CI) is utilized in chemical research for the exploration of new reaction pathways and the development of innovative synthetic methods. Its unique properties and reactivity contribute to the advancement of chemical science and the discovery of novel compounds with potential applications in various industries.

Upstream product

• 78086-72-3 (2R,3S)-4-desoxy-2,3-O-isopropylidene-L-threonate de methyle 
• 67812-34-4 (4R,5S)-5-Methanesulfonyloxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 1336854-09-1 biphenyl-4-ylmethyl (4R,5S)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylate 
• 78016-90-7 (4R,5R)-methyl 5-iodomethyl-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 67844-13-7 methyl (4R,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 37031-29-1 (-)-dimethy-2,3-O-isopropylidene-L-tartrate 
• 114951-10-9 N-<(4R,5S)-2,2,5-trimethyl-1,3-dioxolane-4-carbonyl>bornane-10,2-sultam 
• 67-64-1 acetone 
• 78513-04-9 (4S,5S)-p-toluolsulfonsaeure<(5-benzyloxymethyl-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl>ester 

Downstream Products

• 78016-91-8 Benzoic acid 2-oxo-2-((4R,5S)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-ethyl ester 
• 78016-92-9 Benzoic acid (Z)-2-((4S,5S)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-octadec-2-enyl ester 
• 78016-92-9 Benzoic acid (E)-2-((4S,5S)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-octadec-2-enyl ester 
• 81703-36-8 1-((4R,5S)-2,2,5-trimethyl-1,3-dioxolan-4-yl)ethanone 
• 107914-67-0 N-<(4R,5S)-2,2,5-Trimethyl-1,3-dioxolan-4-ylcarbonyl>-DL-2-phenylglycin-3-methyl-2-butenylester 
• 107914-72-7 2-(3-Methyl-2-butenyl)-4-phenyl-2-<(4R,5S)-2,2,5-trimethyl-1,3-dixolan-4-yl>-5(2H)-oxazolon 

Relevant articles and documents

Scalable synthesis of enantiomerically pure syn -2,3-dihydroxybutyrate by sharpless asymmetric dihydroxylation of p -phenylbenzyl crotonate

An efficient four-step synthetic route to the useful chiral building block (2R,3S)-dihydroxybutyric acid acetonide in >95% ee is detailed. The sequence is readily scaled, requires no chromatography, and allows for efficient recycling of p-phenylbenzyl alcohol, an expedient for enantio- and diastereoenrichment by recrystallization.

ENZYMATIC ENANTIOSELECTIVE HYDROLYSIS OF 2,2-DIMETHYL-1,3-DIOXOLANE-4-CARBOXYLIC ESTERS

2,2-dimethyl-1,3-dioxolane-4-carboxylic acid derived chiral building blocks were prepared from substituted α,β-unsaturated acids with high enantiomeric purities by enzymatic hydrolysis of their n.butyl esters.

Asymmetric Dihydroxylations of β-Substituted N-(α,β-Enolyl)bornane-10,2-sultams

Pure (E)- or (Z)-enoylsultams 2 were oxidized with OsO4/N-methylmorpholine N-oxide in a stereospecific and highly ?-face selective manner.Acetalization of the resulting 1,2-diols furnished, after purification, the stable, crystalline acetals 6 in >99percent d.e. and in 63-74percent overall yield from 2.Reductive or hydrolytic cleavage of 6 gave enantiometrically pure alcohols 8 or carboxylic acids 9 with recovery of the sultam auxiliary 1.

Chain Elongation of Carbohydrates: Synthesis of Pyrazoles from Optically Active Carboxylic Acids

By chain elongation via the C-phenylglycine method optically active carboxylic acids may be converted into 3-substituted pyrazoles in few steps with good chemical yields.Starting with peracetylated glyconic acids this technique permits an easy access to u

SYNTHESIS OF (-)-DIHYDROMAHUBANOLIDE B AND (-)-ISODIHYDROMAHUBANOLIDE B

The total synthesis of (-)-dihydromahubanolide B and (-)-isodihydromahubanolide B isolated from the Amazonian Lauraceae Licaria mahuba (Samp.) Kosterm was achieved starting from (-)-methyl 5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane-4-carboxylate which was readily available from L-(+)-tartaric acid.