107984-25-8

Upstream product

• 107968-12-7 1-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-ethanol 
• 50622-10-1 (-)-(2S,3S)-1,4-dimethoxy-2,3-butanediol 
• 1826-67-1 vinyl magnesium bromide 
• 107968-14-9 2-keto-1-phenyl-1-propanone (2S,3S)-1,4-dimethoxy-2,3-butylene acetal 
• 73611-99-1 2-Hydroxypropiophenone dimethylacetal 

Relevant academic research and scientific papers

Asymmetric Synthesis Using Chiral Acetals: Studies on the Nucleophilic Addition of Organometallics to Chiral α-Keto Acetals in Open-Chain Systems

Nucleophilic addition of organometallic reagents (Grignard reagents and organolithium reagents) to three chiral α-keto acetals (1a-c) in open-chain systems was studied.The reactions of the chiral α-keto acetals (1a,1b) having a chiral auxiliary as a keton

DIASTEREOSELECTIVE NUCLEOPHILIC ADDITION TO CHIRAL OPEN-CHAIN α-KETOACETALS: SYNTHESIS OF (R)- AND (S)-MEVALOLACTONE

Highly stereoselective addition of Grignard reagents to chiral open-chain α-ketoacetals (3a,3b) has been attained.Application of the reaction to syntheses of the key intermediates (6,8) for (R)- and (S)-mevalolactone is also described.