1079991-68-6Relevant articles and documents
FLUORINE-CONTAINING THALIDOMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING THE SAME
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, (2021/09/29)
PROBLEM TO BE SOLVED: To provide a novel thalidomide three-agents derivative that has a similar structure to those of three thalidomide agents (thalidomide, lenalidomide, pomalidomide) but has oxidative metabolism resistant activity and can avoid teratogenicity. SOLUTION: A fluorinated thalidomide three-agents derivative is represented by the formula (1) (R1, R2, R3 are the same or different to represent H or F, where at least one of R1, R2, R3 is F; R4 is H or an optionally substituted hydroxy, alkoxy, acyl, acyloxy or alkyl group; X is H, F or an optionally substituted amino group; Y is -C(=O)- or -CH2-). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
HEPATITIS B CORE PROTEIN MODULATORS
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Page/Page column 146, (2018/04/13)
The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound of formula:
BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 84, (2010/01/29)
The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
