321-21-1

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H7FO/c1-9-7-5-3-2-4-6(7)8/h2-5H,1H3

Upstream product

• 446-29-7 1-(4-fluoro-2-methylphenyl)ethanone 
• 456-22-4 4-Fluorobenzoic acid 
• 74-88-4 methyl iodide 
• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 594-19-4 tert.-butyl lithium 
• 598-30-1 sec.-butyllithium 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 201230-82-2 carbon monoxide 
• 352-70-5 m-Fluorotoluene 
• 557-91-5 1,1-Dibromoethane 
• 124-38-9 carbon dioxide 
• 79825-05-1 2-methyl-4-fluoro-4'-methylbenzophenone 
• 147754-12-9 4-fluoro-2-methylbenzonitrile 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 

Downstream Products

• 21900-43-6 4-fluoro-2-methylbenzoyl chloride 
• 1026030-54-5 5-(chlorosulfonyl)-4-fluoro-2-methylbenzoic acid 
• 190367-38-5 4-fluoro-2-methyl-5-(methylsulfonyl)benzoic acid 
• 1026482-41-6 4-Fluoro-5-methanesulfonyl-2-methyl-benzoyl chloride 
• 190367-94-3 4-Hydroxy-5-methanesulfonyl-2-methyl-benzoic acid 
• 190367-50-1 4-fluoro-5-methanesulfonyl-2-methyl-benzoic acid methyl ester 
• 190367-90-9 5-Methanesulfonyl-4-methoxy-2-methyl-benzoic acid methyl ester 
• 1027515-32-7 5-Methanesulfonyl-2-methyl-4-propylsulfanyl-benzoyl chloride 
• 190367-76-1 5-Methanesulfonyl-2-methyl-4-propylsulfanyl-benzoic acid 
• 176309-15-2 N-diaminomethylene-2-methyl-4-fluoro-5-methylsulphonylbenzamide 
• 190367-77-2 4-tert-Butylsulfanyl-5-methanesulfonyl-2-methyl-benzoic acid 
• 177970-06-8 4-tert-Butoxy-5-methanesulfonyl-2-methyl-benzoic acid methyl ester 
• 177969-77-6 N-diaminomethylene-2-methyl-4-methoxy-5-methylsulfonylbenzamide 
• 190368-19-5 5-Methanesulfonyl-2-methyl-4-phenylamino-benzoic acid 

Relevant academic research and scientific papers

Simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid

The invention relates to a simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid. According to the synthesis method, m-fluorotoluene and acetyl chloride are takenas starting raw materials, and are subjected to a Friedel-Crafts acylation reaction under the catalytic action of anhydrous aluminum trichloride, a haloform reaction is carried out with sodium hypochlorite, two isomers of 4-fluoro-2-methyl benzoic acid and 2-fluoro-4-methyl benzoic acid are simultaneously obtained after hydrolysis, and the isomers are separated through re-crystallizing so as to obtain the target product 4-fluoro-2-methylbenzoic acid. The route is mild in reaction condition, low in cost, environment-friendly and suitable for industrial production.

Chemical synthesis method of 4-fluoro-2-methyl benzoic acid

The invention relates to a chemical synthesis method of 4-fluoro-2-methyl benzoic acid. According to the synthesis method, m-fluorotoluene and trichloroacetyl chloride are used as starting raw materials, and are subjected to a Friedel-Crafts acylation reaction under the catalytic action of anhydrous aluminum trichloride, hydrolysis and acidification are performed under an alkaline condition to obtain two isomers of 4-fluoro-2-methyl benzoic acid and 2-fluoro-4-methyl benzoic acid, and the isomers are separated through re-crystallizing to obtain the target product 4-fluoro-2-methylbenzoic acid.The method has the advantages of accessible raw materials, mild reaction conditions and low cost, and is suitable for industrial production.

Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids

A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.

Site- and regio-selective incorporation of carbon dioxide into the C(sp2)Si bond of benzosilacyclobutenes

A reaction of benzosilacyclobutenes with carbon dioxide is catalyzed by a nickel complex having an N-heterocyclic carbene ligand. Carbon dioxide inserts into the C(sp2)Si bond in a site- and regio-selective manner to form a carboncarbon bond, furnishing benzoic acid derivatives.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

The present invention is directed to compounds of formula (I), wherein R1 is a ring and n is a number from 1 to 8. The invention also relates to use of the compounds in therapy as metabotropic glutamate receptor modulators, particularly in neurological and psychiatric disorders.

Synthesis of aromatic carboxylic acids by carbonylation of aryl halides in the presence of epoxide-modified cobalt carbonyls as catalysts

A new procedure was developed for synthesis of aromatic and heteroaromatic acids and their derivatives (esters, salts) by carbonylation of the corresponding aryl halides. The acids are selectively formed in a high yield under very mild conditions. Highly active catalytic systems, base-containing alcoholic solutions of cobalt carbonyl modified with epoxides, were used to activate aryl halides. 2005 Pleiades Publishing, Inc.

The first regioselective metalation and functionalization of unprotected 4-halobenzoic acids

(Chemical Equation Presented) By treatment with s-BuLi, s-BuLi/TMEDA, or t-BuLi at ～-78°C, 4-fluoro- and 4-chlorobenzoic acids (1a,b) are metalated preferentially in the position adjacent to the carboxylate. A complete reversal in regioselectivity is observed for 1a when treated with LTMP; a sequential process involving a rapid intraaggregate lithiation through a quasi dianion complex "QUADAC" is postulated to explain the unusual reactivity of Me2S2 and I2.

ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES

The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.

Aromatic heterocyclic derivatives as enzyme inhibitors

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.