108-15-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(DIMETHYLAMINO)ISOPROPYLAMINE is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new and effective compounds for medical and agricultural applications.
Used in Specialty Chemical Production:
1-(DIMETHYLAMINO)ISOPROPYLAMINE serves as a catalyst and intermediate in the production of specialty chemicals, enhancing the efficiency and selectivity of chemical reactions, and facilitating the synthesis of complex organic molecules.
Used in Personal Care and Cosmetics Industry:
1-(DIMETHYLAMINO)ISOPROPYLAMINE is used as a stabilizer and pH adjuster in personal care products and cosmetics, ensuring product stability and maintaining the desired pH levels for optimal performance and consumer safety.

InChI:InChI=1/C5H14N2/c1-5(6)4-7(2)3/h5H,4,6H2,1-3H3

Upstream product

• 108-16-7 1-methyl-2-N,N-dimethylaminoethanol 
• 15364-56-4 dimethylaminoacetone 

Downstream Products

• 6515-61-3 3-(4-chloro-phenethyl)-5-(2-dimethylamino-1-methyl-ethyl)-[1,3,5]thiadiazinane-2-thione 
• 18997-71-2 (2-Dimethylamino-1-methyl-ethyl)-dithiocarbamic acid 
• 39265-07-1 N-(1-methyl-2-dimethylaminoethyl)-2,2'-dihydroxy-diphenylketoimin 
• 17173-94-3 1-N-Dimethylamino-2-propylamino-p-trimethylsilylbenzamid 
• 102535-20-6 N-(2-Dimethylamino-1-methyl-ethyl)-2-methoxy-5-sulfamoyl-benzamide 
• 116143-20-5 3-(2,4-DICHLORO-5-FLUOROPHENYL)-3-OXO-2-(((2-DIMETHYLAMINO-1-METHYLETHYL) AMINO) METHYLENE)-PROPANOIC ACID ETHYLESTER 
• 500214-47-1 N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N,N-dimethylamino)-1-methylethyl]-2-iodo-4,5-dimethoxybenzamide 
• 947397-78-6 C₂₃H₃₄FN₃O 
• 600698-23-5 N₁,N₁-Dimethyl-N₂-(4-nitro-phenyl)-propane-1,2-diamine 
• 92606-02-5 N-[(2-Dimethylamino-1-methyl)ethyl]-4'-chloroflavone-8-carboxamide 
• 92606-10-5 N-[(2-Dimethylamino-1-methyl)ethyl]-3'-methylflavone-8-carboxamide 

Relevant academic research and scientific papers

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity

A series of cryptolepine derivatives has been synthesized through the incorporation of short basic side-chains in the C-11 position of the 10H-indolo[3,2-b]quinoline scaffold. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum W2 strain, showing IC50 values between 22 and 184 nM, while their cytotoxicity was assessed using HUVEC cells, revealing three compounds with a selectivity ratio higher than 10. The most selective of these derivatives, 4d, with a selectivity ratio of 46, was also the least cytotoxic of the series.

Incorporation of basic side chains into cryptolepine scaffold: Structure-antimalarial activity relationships and mechanistic studies

The synthesis of cryptolepine derivatives containing basic side-chains at the C-11 position and their evaluations for antiplasmodial and cytotoxicity properties are reported. Propyl, butyl, and cycloalkyl diamine side chains significantly increased activity against chloroquine-resistant Plasmodium falciparum strains while reducing cytotoxicity when compared with the parent compound. Localization studies inside parasite blood stages by fluorescence microscopy showed that these derivatives accumulate inside the nucleus, indicating that the incorporation of a basic side chain is not sufficient enough to promote selective accumulation in the acidic digestive vacuole of the parasite. Most of the compounds within this series showed the ability to bind to a double-stranded DNA duplex as well to monomeric hematin, suggesting that these are possible targets associated with the observed antimalarial activity. Overall, these novel cryptolepine analogues with substantially improved antiplasmodial activity and selectivity index provide a promising starting point for development of potent and highly selective agents against drug-resistant malaria parasites.

An efficient and general synthesis of primary amines by ruthenium-catalyzed amination of secondary alcohols with ammonia

Atom efficiency and selectivity are the key features of the first homogeneously catalyzed amination of secondary alcohols with ammonia to give the corresponding primary amines (see scheme). This novel amination method relies on the commercially available catalyst [Ru3(CO)12]/ cataCXium PCy and does not require any additional source of hydrogen.

Method of treating chloroquine-resistant malaria with aminoquinoline derivatives

Novel aminoquinoline derivatives of the general formula STR1 are described. Also described are methods for the treatment of malaria pathogens, particularly chloroquine-resistance malaria pathogens with compounds of formula I or the pharmaceutically acceptable salts and hydrolyzable esters thereof.