108-15-6Relevant articles and documents
Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity
Lavrado, Joao,Paulo, Alexandra,Gut, Jiri,Rosenthal, Philip J.,Moreira, Rui
, p. 1378 - 1381 (2008)
A series of cryptolepine derivatives has been synthesized through the incorporation of short basic side-chains in the C-11 position of the 10H-indolo[3,2-b]quinoline scaffold. Their antiplasmodial activity was evaluated in vitro against the chloroquine resistant Plasmodium falciparum W2 strain, showing IC50 values between 22 and 184 nM, while their cytotoxicity was assessed using HUVEC cells, revealing three compounds with a selectivity ratio higher than 10. The most selective of these derivatives, 4d, with a selectivity ratio of 46, was also the least cytotoxic of the series.
An efficient and general synthesis of primary amines by ruthenium-catalyzed amination of secondary alcohols with ammonia
Imm, Sebastian,Neubert, Lorenz,Neumann, Helfried,Beller, Matthias
supporting information; experimental part, p. 8126 - 8129 (2011/02/22)
Atom efficiency and selectivity are the key features of the first homogeneously catalyzed amination of secondary alcohols with ammonia to give the corresponding primary amines (see scheme). This novel amination method relies on the commercially available catalyst [Ru3(CO)12]/ cataCXium PCy and does not require any additional source of hydrogen.
