108026-45-5

Basic information

• Product Name: 1-benzyl-3-cyano-4-methylpyrrole
• Synonyms: 1-benzyl-3-cyano-4-methylpyrrole
• CAS NO: 108026-45-5
• Molecular Weight: 196.252
• Mol File: 108026-45-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-cyano-4-methylpyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-cyano-4-methylpyrrole(108026-45-5)
• EPA Substance Registry System: 1-benzyl-3-cyano-4-methylpyrrole(108026-45-5)

Safety Data

• Hazardous Substances Data: 108026-45-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 40167-38-2 4-methyl-1H-pyrrole-3-carbonitrile 

Relevant articles and documents

Efficient preparation of [1-15N]-3-cyano-4-methyl-1H-pyrrole by a Wittig-based strategy

3-Cyano-4-methyl-1H-pyrrole (1) was prepared by a new Wittig procedure from simple, commercially available starting materials in four steps with an overall yield of 39%. Similarly, [1-15N]-3-cyano-4-methyl-1H-pyrrole (1a) was prepared starting from [15N]-phthalimide. In this synthesis, Wittig coupling was used to form the central C-C bond of intermediate 6, which has nitrile and methyl substituents. Upon deprotection and cyclization pyrrole 1 is obtained directly in one pot. This scheme also allows stable isotope incorporation at any position or a combination of positions. 3-Cyano-4-methyl-1H-pyrrole was converted into the novel 1-benzyl-3-cyano-4- methylpyrrole and the novel 4-methyl-1H-pyrrole-3-aldehyde. It is clear that this novel Wittig procedure has a wide scope that will allow the easy preparation of many new pyrrole systems. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.