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1081111-05-8

2-phenyl-1-{2-[4-(3-acetylaminophenyl)piperidin-1-yl]ethyl}-1H-benzimidazole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1081111-05-8 Structure

  • Basic information

    1. Product Name: 2-phenyl-1-{2-[4-(3-acetylaminophenyl)piperidin-1-yl]ethyl}-1H-benzimidazole
    2. Synonyms: 2-phenyl-1-{2-[4-(3-acetylaminophenyl)piperidin-1-yl]ethyl}-1H-benzimidazole
    3. CAS NO:1081111-05-8
    4. Molecular Formula:
    5. Molecular Weight: 438.572
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1081111-05-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-phenyl-1-{2-[4-(3-acetylaminophenyl)piperidin-1-yl]ethyl}-1H-benzimidazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-phenyl-1-{2-[4-(3-acetylaminophenyl)piperidin-1-yl]ethyl}-1H-benzimidazole(1081111-05-8)
    11. EPA Substance Registry System: 2-phenyl-1-{2-[4-(3-acetylaminophenyl)piperidin-1-yl]ethyl}-1H-benzimidazole(1081111-05-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1081111-05-8(Hazardous Substances Data)

1081111-05-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1081111-05-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,1,1,1 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1081111-05:
(9*1)+(8*0)+(7*8)+(6*1)+(5*1)+(4*1)+(3*1)+(2*0)+(1*5)=88
88 % 10 = 8
So 1081111-05-8 is a valid CAS Registry Number.

1081111-05-8Downstream Products

1081111-05-8Relevant articles and documents

Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists

Lim, Chae Jo,Kim, Nakjeong,Lee, Eun Kyoung,Lee, Byung Ho,Oh, Kwang-Seok,Yoo, Sung-Eun,Yi, Kyu Yang

, p. 2309 - 2312 (2011/05/15)

Compounds containing 2-arybenzimidazole ring systems linked to arylpiperidines were synthesized and evaluated as MCH-R1 antagonists. The results of structure-activity relationship studies led to the identification of compound 4c as a potent MCH-R1 antagonist (IC50 = 1 nM). This compound also has good metabolic stability, and favorable pharmacokinetic and brain penetration properties. However 4c was found to be potent inhibitor of the hERG potassium channel.

IMIDAZOLE DERIVATIVES HAVING ARYL PIPERIDINE SUBSTITUENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

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Page/Page column 30-31, (2009/01/20)

The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.

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