108147-55-3Relevant academic research and scientific papers
Structure-activity relationship of highly potent galactonoamidine inhibitors toward β-galactosidase (Aspergillus oryzae)
Fan, Qiu-Hua,Claunch, Kailey A.,Striegler, Susanne
, p. 8999 - 9009 (2015/03/14)
A small library of 22 N-substituted galactonoamidines was synthesized, and their structure-activity relationship for inhibition of the hydrolytic activity of β-galactosidase (Aspergillus oryzae) was evaluated. A fast screening assay in 96-well plate forma
All eight stereoisomeric D-glyconic-δ-lactams: Synthesis, conformational analysis, and evaluation as glycosidase inhibitors
Nishimura, Yoshio,Adachi, Hayamitsu,Satoh, Takahiko,Shitara, Eiki,Nakamura, Hikaru,Kojima, Fukiko,Takeuchi, Tomio
, p. 4871 - 4882 (2007/10/03)
An efficient and general synthetic route to all eight stereoisomeric D-glycono-δ-lactams has been developed. The strategy involves, as a key step, a stereodivergent δ-lactam formation with configurational retention or inversion at C-4 of a starting γ-lactone to lead to two epimers of δ-lactam from one parent γ-lactone. Conformations of eight glycono-δ-lactams were examined by X-ray crystallographic analysis and molecular modeling. Analyses of conformation and glycosidase-inhibition provide useful information for the design of new glycosidase inhibitors.
A Facile Transformation of Sugar Lactones to Azasugars
Overkleeft, Herman S.,Wiltenburg, Jim van,Pandit, Upendra K.
, p. 4215 - 4224 (2007/10/02)
The synthesis of pyrano- and furano- sugar lactams from the corresponding lactones, in a five step sequence, is described.
