294203-99-9

Upstream product

• 294203-97-7 2,3-di-O-methoxymethyl-5,6-O-isopropylidene-D-galactono-γ-lactone 
• 56710-46-4 5,6-O-isopropylidene-D-galactonic acid γ-lactone 
• 294204-00-5 5-keto-2,3-di-O-methoxymethyl-6-O-triphenylmethyl-L-arabinohexonic acid γ-lactone 
• 76-83-5 trityl chloride 
• 294203-98-8 2,3-di-O-methoxymethyl-D-galactono-γ-lactone 

Downstream Products

• 294204-00-5 5-keto-2,3-di-O-methoxymethyl-6-O-triphenylmethyl-L-arabinohexonic acid γ-lactone 
• 294204-02-7 5-azido-5-deoxy-2,3-di-O-methoxymethyl-6-O-triphenylmethyl-D-galactono-γ-lactone 
• 294204-04-9 2,3-di-O-methoxymethyl-6-O-triphenylmethyl-D-glucono-δ-lactam 
• 294204-03-8 2,3-di-O-methoxymethyl-6-O-triphenylmethyl-D-galactono-δ-lactam 
• 294204-01-6 2,3-di-O-methoxymethyl-6-O-triphenylmethyl-L-altrono-γ-lactone 
• 108147-55-3 D-galactono-δ-lactam 
• 14904-83-7 nojirimycin-δ-lactam 

Relevant academic research and scientific papers

All eight stereoisomeric D-glyconic-δ-lactams: Synthesis, conformational analysis, and evaluation as glycosidase inhibitors

An efficient and general synthetic route to all eight stereoisomeric D-glycono-δ-lactams has been developed. The strategy involves, as a key step, a stereodivergent δ-lactam formation with configurational retention or inversion at C-4 of a starting γ-lactone to lead to two epimers of δ-lactam from one parent γ-lactone. Conformations of eight glycono-δ-lactams were examined by X-ray crystallographic analysis and molecular modeling. Analyses of conformation and glycosidase-inhibition provide useful information for the design of new glycosidase inhibitors.