108175-82-2

Upstream product

• 108175-81-1 2-Phenylthiazolo<5,4-c>pyridine-7(6H)-one 
• 3474-90-6 β-(2-Phenylthiazol-4-yl)acrylic acid 
• 20949-81-9 2-phenyl-thiazole-4-carbaldehyde 
• 78359-00-9 4-(iodomethyl)-2-phenyl-1,3-thiazole 
• 4771-31-7 2-phenyl-4-chloromethylthiazole 
• 2227-79-4 benzenecarbothioamide 

Relevant academic research and scientific papers

Kinase inhibitor, and preparation and application of kinase inhibitor

The invention provides a compound shown as a formula (I), or a stereoisomer, a tautomer, nitrogen oxide, metabolite, a prodrug, pharmaceutically acceptable salt or solvate of the compound, and application of the compound to preparing drugs or drug compositions for treating Pim kinase-mediated diseases.

Synthesis of 2-Aryl-6-carbethoxythiazolopyridine

Startinf from readily available 2-aryl-5-formyl-4-methylthiazole, 2-aryl-6-carbethoxythiazolopyridine was prepared. β-(2-Phenylthiazol-4-yl)acrylic acid was converted to the corresponding azide (VI).Cyclization of compound VI afforded 2-phenylthiaz